Table 3 Diagnostic performance of biomarkers and biomarker combinations for AKI defined by KDIGO occurring at 24 h
Biomarker | Cutoff value | Sensitivity | Specificity | Positive LR | Negative LR |
|---|---|---|---|---|---|
uCHI3L1 (ng/mL) | > 2.1 | 61.2% (46.2, 74.8) | 72.8% (69.1, 76.3) | 2.25 (1.74, 2.92) | 0.53 (0.37, 0.76) |
NephroCheck Risk® (ng/mL)2/1000 | > 0.3 | 73.5% (58.9, 85.1) | 56.6% (52.6, 60.6) | 1.69 (1.34, 2.05) | 0.47 (0.29, 0.75) |
NephroCheck Risk® (ng/mL)2/1000 | > 2.0 | 28.6% (16.6, 43.3) | 87.7% (84.9, 90.2) | 2.33 (1.43, 3.80) | 0.81 (0.68, 0.97) |
uCHI3L1•TIMP-2 (ng/mL)2 | > 5.5 | 65.3% (50.4, 78.3) | 67.3% (63.4, 71.0) | 2.00 (1.58, 2.52) | 0.52 (0.35, 0.76) |
uCHI3L1•IGFBP7 (ng/mL)2 | > 459.8 | 46.9% (32.5, 61.7) | 80.7% (77.3, 83.7) | 2.43 (1.73, 3.41) | 0.66 (0.50, 0.86) |
uCH3L1• NephroCheck Risk® (ng/mL)3/1000 | > 3.3 | 48.9% (34.4, 63.7) | 82.2% (78.9, 85.1) | 2.75 (1.97, 3.83) | 0.62 (0.47, 0.82) |