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Table 3 Diagnostic performance of biomarkers and biomarker combinations for AKI defined by KDIGO occurring at 24 h

From: Urinary cell cycle arrest biomarkers and chitinase 3-like protein 1 (CHI3L1) to detect acute kidney injury in the critically ill: a post hoc laboratory analysis on the FINNAKI cohort

BiomarkerCutoff valueSensitivitySpecificityPositive LRNegative LR
uCHI3L1 (ng/mL)> 2.161.2% (46.2, 74.8)72.8% (69.1, 76.3)2.25 (1.74, 2.92)0.53 (0.37, 0.76)
NephroCheck Risk® (ng/mL)2/1000> 0.373.5% (58.9, 85.1)56.6% (52.6, 60.6)1.69 (1.34, 2.05)0.47 (0.29, 0.75)
NephroCheck Risk® (ng/mL)2/1000> 2.028.6% (16.6, 43.3)87.7% (84.9, 90.2)2.33 (1.43, 3.80)0.81 (0.68, 0.97)
uCHI3L1•TIMP-2 (ng/mL)2> 5.565.3% (50.4, 78.3)67.3% (63.4, 71.0)2.00 (1.58, 2.52)0.52 (0.35, 0.76)
uCHI3L1•IGFBP7 (ng/mL)2> 459.846.9% (32.5, 61.7)80.7% (77.3, 83.7)2.43 (1.73, 3.41)0.66 (0.50, 0.86)
uCH3L1• NephroCheck Risk® (ng/mL)3/1000> 3.348.9% (34.4, 63.7)82.2% (78.9, 85.1)2.75 (1.97, 3.83)0.62 (0.47, 0.82)