|Increased ACE2 increases infectivity of SARS [6, 10]|
|Decreased ACE2 expression decreases infectivity of SARS [6, 10]|
|SARS-CoV-2 utilizes ACE2 to enter cells like SARS-CoV-1 |
|Patients taking ACE inhibotors and ARBs have increased ACE2 expression |
|Exogenous angiotensin II decreases ACE2 expression [12, 13]|
|Patient with hypertension are at high risk for severe COVID infection and death |
Exogenous angiotensin II via reduction ACE2 expression in the vasculature and heart may decrease viral propagation and thus improve outcomes.