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Table 1 Information supporting the use of angiotensin II in COVID-19 disease

From: COVID-19 and the RAAS—a potential role for angiotensin II?

Increased ACE2 increases infectivity of SARS [6, 10]
Decreased ACE2 expression decreases infectivity of SARS [6, 10]
SARS-CoV-2 utilizes ACE2 to enter cells like SARS-CoV-1 [6]
Patients taking ACE inhibotors and ARBs have increased ACE2 expression [15]
Exogenous angiotensin II decreases ACE2 expression [12, 13]
Patient with hypertension are at high risk for severe COVID infection and death [5]
Hypothesis:
Exogenous angiotensin II via reduction ACE2 expression in the vasculature and heart may decrease viral propagation and thus improve outcomes.