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Table 2 Multivariate analyses of factors associated with AKI and severe AKI

From: Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study

Variable

Adjusted odds ratio

LCI

UCI

p

AKI

 Hydroxocobalamin

1.597

1.055

2.419

0.027

 Severe burn

2.91

1.841

4.601

< 0.001

 SOFA score without renal item

1.003

0.891

1.129

0.963

 Prehospital GCS

1.064

0.997

1.136

0.063

 Aminoglycoside during hospitalization

2.903

1.184

4.473

< 0.001

 Glycopeptide during hospitalization

1.731

0.773

3.877

0.182

 Admission plasma lactate

1.105

1.034

1.182

0.003

 Age

1.009

0.997

1.021

0.154

 Peripheral arterial obstructive disease

0.913

0.308

2.713

0.87

 Diabetes mellitus

1.487

0.726

3.046

0.278

 Chronic hypertension

2.134

1.248

3.649

0.006

 CKD

0.947

0.119

7.504

0.959

 Prehospital cardiac arrest

0.418

0.025

7.096

0.546

 Vasopressor at admission

1.778

0.93

3.396

0.081

 Maximum CPK

1.081

0.997

1.242

0.269

 Contrast agent

1.445

0.803

2.601

0.219

 SAPS2

1.021

1.006

1.036

0.009

 Center

1.014

0.976

1.053

0.484

 Interaction between prehospital cardiac arrest and hydroxocobalamin

2.245

0.125

40.367

0.583

Severe AKI

 Hydroxocobalamin

1.772

1.137

2.762

0.012

 Age

1.006

0.993

1.019

0.394

 Peripheral arterial obstructive disease

0.552

0.183

1.668

0.292

 Diabetes mellitus

1.201

0.582

2.479

0.619

 Chronic hypertension

2.045

1.168

3.579

0.012

 Prehospital cardiac arrest

0.775

0.043

14.12

0.863

 Severe burn

2.157

1.276

3.645

0.004

 SOFA score at admission without renal item

1.047

0.924

1.185

0.471

 CKD

2.407

0.285

20.299

0.418

 Vasopressor at admission

1.298

0.653

2.579

0.456

 Prehospital GCS

1.04

0.973

1.11

0.248

 Admission plasma lactate

1.151

1.062

1.248

0.001

 Maximum CPK

1.099

0.904

1.337

0.324

 Aminoglycoside during hospitalization

2.418

1.539

3.801

< 0.001

 Contrast agent

0.889

0.476

1.663

0.713

 Glycopeptide during hospitalization

2.873

1.318

6.261

0.008

 SAPS2

1.02

1.006

1.035

0.006

 Center

1.042

0.998

1.089

0.061

 Interaction between prehospital cardiac arrest and hydroxocobalamin

0.412

0.02

8.331

0.563

  1. AKI acute kidney injury, LCI lower confidence interval, UCI upper confidence interval, p p value, SOFA score sequential organ failure assessment, GCS Glasgow coma scale, CKD chronic kidney disease, CPK creatinine phosphokinase, SAPS2 simplified acute physiology score 2
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