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Fig. 4 | Critical Care

Fig. 4

From: Impact of acyclovir use on survival of patients with ventilator-associated pneumonia and high load herpes simplex virus replication

Fig. 4

ac Development of clinical parameters in high viral load patients after start of antiviral treatment. Day 0 (d0) was defined as the date of first detection of significant HSV-1/2 replication in untreated patients or as the date of acyclovir treatment start for patients receiving. a Circulatory function as measured by norepinephrine doses given for circulatory support. b Respiratory function as measured by PaO2/FiO2 ratio. c Pulmonary infiltrates as measured by a semiquantitative score. In a and b, p values are from the Friedman test, while horizontal brackets indicate significant differences (*p < 0.05) between time points by Conover’s post hoc test. In c, the Wilcoxon signed-rank test was used to compare the last available X-ray or CT before d0 to the maximum change within a time span of 3 to 15 days

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