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Table 2 Adjusted association of tidal volume, driving pressure, and respiratory system compliance with 30-day mortality. Coefficient estimates from multivariable logistic regressions using generalized linear models (GLM). p values were adjusted for multiple hypothesis testing by limiting the false discovery rate (FDR) per the method of Benjamini and Hochberg [9]

From: Driving pressure is not associated with mortality in mechanically ventilated patients without ARDS

AnalysisGroupOutcomeExposureOR (95% CI)ppFDR
PrimaryNon-ARDS30-day mortalityDriving pressure1.02 (0.97 to 1.06)0.463 
SecondaryNon-ARDS30-day mortalityTidal volume1.22 (1.07 to 1.39)0.0030.01
SecondaryNon-ARDS30-day mortalityCompliance> 1 (0.99 to 1.01)0.8900.89
ConfirmatoryARDS30-day mortalityDriving pressure1.1 (1.06 to 1.14)< 0.001< 0.001
ConfirmatoryARDS30-day mortalityTidal volume1.17 (1.04 to 1.31)0.0070.015
ConfirmatoryARDS30-day mortalityCompliance< 1 (0.99 to > 1)0.3140.472