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Table 2 Adjusted association of tidal volume, driving pressure, and respiratory system compliance with 30-day mortality. Coefficient estimates from multivariable logistic regressions using generalized linear models (GLM). p values were adjusted for multiple hypothesis testing by limiting the false discovery rate (FDR) per the method of Benjamini and Hochberg [9]

From: Driving pressure is not associated with mortality in mechanically ventilated patients without ARDS

Analysis

Group

Outcome

Exposure

OR (95% CI)

p

pFDR

Primary

Non-ARDS

30-day mortality

Driving pressure

1.02 (0.97 to 1.06)

0.463

 

Secondary

Non-ARDS

30-day mortality

Tidal volume

1.22 (1.07 to 1.39)

0.003

0.01

Secondary

Non-ARDS

30-day mortality

Compliance

> 1 (0.99 to 1.01)

0.890

0.89

Confirmatory

ARDS

30-day mortality

Driving pressure

1.1 (1.06 to 1.14)

< 0.001

< 0.001

Confirmatory

ARDS

30-day mortality

Tidal volume

1.17 (1.04 to 1.31)

0.007

0.015

Confirmatory

ARDS

30-day mortality

Compliance

< 1 (0.99 to > 1)

0.314

0.472