Table 1 Demographic and clinical characteristics and clinical outcomes of patients with and without ARDS. Central tendencies are reported as median with interquartile ranges
From: Driving pressure is not associated with mortality in mechanically ventilated patients without ARDS
ARDS (N = 1385) | Non-ARDS (N = 1239) | p value | |
|---|---|---|---|
Baseline characteristics | |||
Age, years | 61 (48–72) | 60 (44–70) | 0.007 |
Female, % (n) | 42.1 (583) | 42.0 (520) | 0.98 |
Acute physiology score | 25 (21–30) | 23 (19–28) | < 0.001 |
Charlson Comorbidity Index | 4 (2–6) | 3 (1.5–6) | 0.38 |
PaO2/FiO2 ratio, mm Hg | 120 (83–170) | 194 (121–284) | < 0.001 |
Mild hypoxemia (n) | 340 | 703 | |
Moderate hypoxemia (n) | 675 | 370 | |
Severe hypoxemia (n) | 370 | 166 | |
PaO2, mm Hg | 78 (66–95) | 97 (76–136) | < 0.001 |
PaCO2, mm Hg | 41 (35–48) | 37 (32–43) | < 0.001 |
Ventilator parameters on day 1 | |||
On PRVC, % (n) | 74.0 (1025) | 74.4 (922) | 0.85 |
Set VT, normalized to PBW, mL/kg | 6.3 (6.0–7.6) | 6.6 (6.0–7.8) | 0.04 |
For patients on PRVC, mL/kg | 6.5 (6.0–7.8) | 6.8 (6.1–7.9) | 0.008 |
For patients on other VC, mL/kg | 6.1 (6.0–6.8) | 6.1 (6.0–6.9) | 0.73 |
Measured VT, normalized to PBW, mL/kg | 6.8 (6.2–7.8) | 6.9 (6.3–7.8) | 0.06 |
For patients on PRVC, mL/kg | 6.9 (6.2–7.9) | 6.9 (6.2–7.8) | 0.03 |
For patients on other VC, mL/kg | 6.8 (6.4–7.4) | 6.7 (6.5–7.6) | 0.32 |
Measured VT, mL | 452 (386–516) | 455 (392–520) | 0.76 |
Respiratory rate, min−1 | 23 (19–28) | 21 (18–25) | < 0.001 |
FiO2, % | 45 (40–54) | 42 (40–49) | < 0.001 |
PEEP, cm H2O | 7.5 (5.0–9.9) | 5.0 (5.0–8.0) | < 0.001 |
PPL, cm H2O | 18.7 (16.0–21.9) | 16.6 (14.0–19.6) | < 0.001 |
ΔP, cm H2O | 10.8 (8.9–13.2) | 10.0 (8.1–12.2) | < 0.001 |
CRS, mL/cm H2O | 44.0 (34.1–55.4) | 46.7 (37.8–59.2) | < 0.001 |
Clinical outcomes | |||
30-day mortality, % (n) | 34.1 (472) | 28.7 (356) | 0.004 |
Ventilator-free days, out of 28 days | 18 (0–24) | 21 (0–25) | < 0.001 |
ICU length of stay, days | 7.8 (4.0–13.5) | 6.2 (3.3–12.1) | < 0.001 |