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Table 1 Demographic and clinical characteristics and clinical outcomes of patients with and without ARDS. Central tendencies are reported as median with interquartile ranges

From: Driving pressure is not associated with mortality in mechanically ventilated patients without ARDS

 ARDS (N = 1385)Non-ARDS (N = 1239)p value
Baseline characteristics
 Age, years61 (48–72)60 (44–70)0.007
 Female, % (n)42.1 (583)42.0 (520)0.98
 Acute physiology score25 (21–30)23 (19–28)< 0.001
 Charlson Comorbidity Index4 (2–6)3 (1.5–6)0.38
 PaO2/FiO2 ratio, mm Hg120 (83–170)194 (121–284)< 0.001
  Mild hypoxemia (n)340703 
  Moderate hypoxemia (n)675370 
  Severe hypoxemia (n)370166 
 PaO2, mm Hg78 (66–95)97 (76–136)< 0.001
 PaCO2, mm Hg41 (35–48)37 (32–43)< 0.001
Ventilator parameters on day 1
 On PRVC, % (n)74.0 (1025)74.4 (922)0.85
 Set VT, normalized to PBW, mL/kg6.3 (6.0–7.6)6.6 (6.0–7.8)0.04
  For patients on PRVC, mL/kg6.5 (6.0–7.8)6.8 (6.1–7.9)0.008
  For patients on other VC, mL/kg6.1 (6.0–6.8)6.1 (6.0–6.9)0.73
 Measured VT, normalized to PBW, mL/kg6.8 (6.2–7.8)6.9 (6.3–7.8)0.06
  For patients on PRVC, mL/kg6.9 (6.2–7.9)6.9 (6.2–7.8)0.03
  For patients on other VC, mL/kg6.8 (6.4–7.4)6.7 (6.5–7.6)0.32
 Measured VT, mL452 (386–516)455 (392–520)0.76
 Respiratory rate, min−123 (19–28)21 (18–25)< 0.001
 FiO2, %45 (40–54)42 (40–49)< 0.001
 PEEP, cm H2O7.5 (5.0–9.9)5.0 (5.0–8.0)< 0.001
 PPL, cm H2O18.7 (16.0–21.9)16.6 (14.0–19.6)< 0.001
 ΔP, cm H2O10.8 (8.9–13.2)10.0 (8.1–12.2)< 0.001
 CRS, mL/cm H2O44.0 (34.1–55.4)46.7 (37.8–59.2)< 0.001
Clinical outcomes
 30-day mortality, % (n)34.1 (472)28.7 (356)0.004
 Ventilator-free days, out of 28 days18 (0–24)21 (0–25)< 0.001
 ICU length of stay, days7.8 (4.0–13.5)6.2 (3.3–12.1)< 0.001
  1. CRS static respiratory compliance, FiO2 percent fraction of inhaled oxygen, ΔP driving pressure, PaCO2 pressure of dissolved arterial carbon dioxide, PaO2 pressure of dissolved arterial oxygen, PEEP positive end-expiratory pressure, PRVC pressure-regulated volume control ventilation mode, PBW predicted body weight, PPL plateau pressure, VC volume control ventilation, VT tidal volume