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Table 2 Biomarker plasma levels at day 0 and at day 7 in ARDS cohort

From: Development of a biomarker mortality risk model in acute respiratory distress syndrome

BiomarkerD0 median (Q1, Q3) (N)D7 median (Q1, Q3) (N)P value1
IL-6 (pg/ml)27 (7, 92) 14512 (4, 54) 115< 0.01
IL-8 (pg/ml)150 (67, 359) 201108 (44, 298) 2000.001
IL-1RA (pg/ml)3072(1241, 6545) 2292755 (1067, 5695) 2250.04
MIF (ng/ml)45(29, 78) 24249 (31, 84) 2470.07
NAMPT (ng/ml)60 (34, 74) 24881 (55, 113) 248< 0.001
S1PR3 (ng/ml)577(227, 1458) 231399 (97, 1066) 233< 0.001
Ang-2 (ng/ml)12 (7, 23) 2477 (4, 12) 247< 0.001
IL-1B (pg/ml)44(24, 68) 22839 (20, 61) 233< 0.01
  1. 1P value from Wilcoxon signed rank test comparing the measurements for D0 and D7 for all eight biomarkers. IL-6 interleukin-6, IL-8 interleukin-8, IL-1RA interleukin-1 receptor antagonist, MIF Macrophage migration inhibitory factor, NAMPT nicotinamide phosphoribosyltransferase, S1PR3 sphingosine 1-phosphate receptor 3, Ang-2 angiopoietin-2, IL-1B interleukin 1 beta