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Table 2 Biomarker plasma levels at day 0 and at day 7 in ARDS cohort

From: Development of a biomarker mortality risk model in acute respiratory distress syndrome

Biomarker

D0 median (Q1, Q3) (N)

D7 median (Q1, Q3) (N)

P value1

IL-6 (pg/ml)

27 (7, 92) 145

12 (4, 54) 115

< 0.01

IL-8 (pg/ml)

150 (67, 359) 201

108 (44, 298) 200

0.001

IL-1RA (pg/ml)

3072(1241, 6545) 229

2755 (1067, 5695) 225

0.04

MIF (ng/ml)

45(29, 78) 242

49 (31, 84) 247

0.07

NAMPT (ng/ml)

60 (34, 74) 248

81 (55, 113) 248

< 0.001

S1PR3 (ng/ml)

577(227, 1458) 231

399 (97, 1066) 233

< 0.001

Ang-2 (ng/ml)

12 (7, 23) 247

7 (4, 12) 247

< 0.001

IL-1B (pg/ml)

44(24, 68) 228

39 (20, 61) 233

< 0.01

  1. 1P value from Wilcoxon signed rank test comparing the measurements for D0 and D7 for all eight biomarkers. IL-6 interleukin-6, IL-8 interleukin-8, IL-1RA interleukin-1 receptor antagonist, MIF Macrophage migration inhibitory factor, NAMPT nicotinamide phosphoribosyltransferase, S1PR3 sphingosine 1-phosphate receptor 3, Ang-2 angiopoietin-2, IL-1B interleukin 1 beta