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Table 2 Inflammatory molecules tested in human studies

From: The effect of dexmedetomidine and clonidine on the inflammatory response in critical illness: a systematic review of animal and human studies

Human studies
Inflammatory moleculeAlteration with α2 agonistLocationCitation
Interferon GammaIncreasedSerumKim et al. [52]
Tumour Necrosis Factor- αDecreasedSerumGao et al. [50]
Kang et al. [51]
Memis et al. [57]
Tasdogan et al. [53]
Zhou et al. [55]
Superoxide DismutaseDecreasedSerumGao et al. [50]
MalondialdehydeDecreasedSerumGao et al. [50]
Heme-oxygenase 1DecreasedLung tissueGao et al. [50]
White Cell countDecreasedSerumKang et al. [51]
Zhou et al. [55]
Interleukin-1bDecreasedSerumKang et al. [51]
Memis et al. [57]
Tasdogan et al. [53]
Interleukin-6DecreasedSerumKang et al. [18]
Memis et al. [57]
Tasdogan et al. [53]
Ueki et al. [56]
Venn et al. [54]
Zhou et al. [55]
Interleukin-10DecreasedSerumKang et al. [51]
Zhou et al. [55]
C Reactive ProteinDecreasedSerumKang et al. [51]
Kawazoe et al. [14]
Ueki et al. [56]
Zhou et al. [55]
ProcalcitoninNo statistically significant changeSerumKawazoe et al. [14]
PrealbuminNo statistically significant changeSerumKawazoe et al. [14]
Nuclear Factor Kappa BDecreaseSerumUeki et al. [56]
High Mobility Group Box 1 (HMGB1)DecreaseSerumUeki et al. [56]