Table 1 Inflammatory molecules tested in animal studies
Animal studies | |||
|---|---|---|---|
Inflammatory molecule | Alteration with α2 agonist | Location | Citation |
Myeloperoxidase | Decreased | Lung tissue Bronchoalveolar lavage fluid Epigastric skin tissue flap | Chen et al. [17] Jiang et al. [18] Uysal et al. [19] |
Nuclear factor Kappa B | Decreased | Lung tissue Bronchoalveolar lavage fluid Myocardial tissue | Chen et al. [17] Kong et al. [20] Hofer et al. [21] Wu et al. [22] Zhang et al. [23] Shen et al. [24] |
Nitric Oxide/inducible nitric oxide synthase mRNA | Decreased | Lung tissue Serum Epigastric skin tissue flap | Chen et al. [17] Yang et al. [25] Yang et al. [26] Sugita et al. [27] Uysal et al. [19] |
Tumour Necrosis Factor- α | Decreased | Lung tissue Bronchoalveolar lavage fluid Serum Myocardial tissue | Jiang et al. [18] Loftus et al. [28] Yang et al. [26] Chen et al. [3] Kang et al. [29] Kong et al. [20] Tan et al. [30] Taniguchi et al. [31] Taniguchi et al. [32] Xiang et al. [33] Chen et al. [17] Hofer et al. [21] Qiao et al. [34] Wu et al. [22] Feng et al. [35] Xu et al. [36] Zhang et al. [23] Shen et al. [24] Sugita et al. [27] Zhang et al. [4] |
Interleukin-6 | Decreased | Lung tissue Bronchoalveolar lavage fluid Serum Myocardial tissue | Jiang et al. [18] Yang et al. [25] Chen et al. [17] Kong et al. [20] Tan et al. [30] Feng et al. [35] Taniguchi et al. [31] Taniguchi et al. Xiang et al. [32] Chen et al. [3] Hofer et al. [21] Kang et al. [29] Qiao et al. [34] Zhang et al. [37] Wu et al. [22] Xu et al. [36] Zhang et al. [23] Shen et al. [24] Sugita et al. [27] Zhang et al. [4] |
Toll-like Receptor 4 | Decreased | Lung tissue Intestinal tissue Myocardial tissue | Jiang et al. [18] Chen et al. [17] Wu et al. [22] Zhang et al. [23] Shen et al. [24] Zhang et al. [4] |
Myeloid Differentiation Primary Response 88 (MyD88) | Decreased | Lung tissue Myocardial tissue | Jiang et al. [18] Wu et al. [22] Zhang et al. [23] Zhang et al. [4] |
Interleukin-10 | Decreased | Serum | Szelenyi et al. [38] |
Vascular endothelial growth factor | Increased | Lung tissue | Loftus et al. [28] |
Vascular endothelial growth factor receptors 1 and 2 | Increased | Lung tissue | Loftus et al. [28] |
Interleukin-1b | Decreased | Lung tissue Serum Myocardial tissue | Yang et al. [25] Yang et al. [26] Kong et al. [20] Zhang et al. [37] Xiang et al. [33] Feng et al. [35] Chen et al. [17] Hofer et al. [21] |
Α-7 nicotinic acetylcholine receptor | Increased | Myocardial tissue | Kong et al. [20] |
Organic hyperoxides and superoxide radicals | Decreased | Lung tissue Hepatic tissue Ileal tissue | Chen et al. [17] Filos et al. [39] |
High Mobility Group Box 1 (HMGB1) | Decreased | Lung tissue Renal tissue Myocardial tissue Serum | Loftus et al. [28] Tan et al. [30] Xu et al. [36] Zhang et al. [4] |
Kidney Injury Molecule 1(KIM1) | Decreased | Renal tissue | Tan et al. [30] |
B-Actin | Decreased | Serum | Yang et al. [25] |
Cyclo-oxygenase 2 (COX-2) | Decreased | Serum | Yang et al. [25] Yang et al. [26] |
Prostaglandin E2 (PGE2) | Decreased | Serum | Yang et al. [26] |
Macrophage inflammatory protein 2 (MIP2) | Decreased | Serum | Yang et al. [26] |
Lactate | Decreased | Serum | Chen et al. [17] Miranda et al. [40] Chen et al. [3] |
Malondialdehyde (MDA) | Decreased | Renal tissue Epigastric skin tissue flap | Chen et al. [3] Koca et al. [41] Uysal et al. [19] |