Table 3 Outcome measures between study groups
Outcome parameter | Plasma-Lyte-A (n = 34) | 0.9% saline (n = 32) | P value | Risk ratio (95% CI) |
|---|---|---|---|---|
Primary outcome | ||||
Composite AKI | ||||
AKI based on worst quartiles at 48 h, n (%) | 13 (38.2) | 15 (46.9) | 0.491 | 1.42 (0.53, 3.86) |
AKI based on KDIGO and p-RIFLE at 48 h, n (%) | 3 (8.8) | 1 (3.1) | 0.332 | 3.0 (0.29, 30.44) |
Individual outcomes of composite AKI | ||||
Creatinine >75th percentile, n (%) | 6 (17.6) | 5 (15.6) | 0.837 | 0.87 (0.22, 3.31) |
Urinary NGAL >75th percentile, n (%) | 9 (27.3) | 7 (21.9) | 0.629 | 0.75 (0.23, 2.38) |
GFR < 25th percentile, n (%) | 7 (20.6) | 10 (31.2) | 0.341 | 1.73 (0.56, 5.59) |
Secondary outcomes | ||||
Reduction in AKI at various time points | ||||
0 h, n (%) | 21 (61.8) | 15 (46.9) | 0.225 | 1.82 (0.69, 4.88) |
24 h, n (%) | 4 (11.8) | 3 (9.4) | 0.753 | 1.28 (0.26, 6.27) |
48 h, n (%) | 3 (8.8) | 1 (3.1) | 0.332 | 3.0 (0.29, 30.44) |
Time to resolution of AKI (hours) | 22.1 (13.8, 30.5) | 18.8 (15.1, 24.3) | 0.494 | 0.98 (0.94, 1.03) |
Time to reach DKA endpoint (hours) | 14.5 (12, 20) | 16 (8, 20) | 0.472 | 0.96 (0.86, 1.13) |
Chloride elevation first 4 h | 3.5 (0.75, 7.25) | 4.0 (1, 10) | 0.403 | |
Chloride elevation first 8 h | 4.0 (0.50, 8.50) | 6.0 (1, 9.5) | 0.608 | |
Need for RRT, n (%) | 2 (5.9) | 0 (0) | 0.164 | |
Need for ventilation, n (%) | 2 (5.9) | 1 (3.1) | 0.591 | |
Mortality in hospital, n (%) | 2 (5.9) | 0(0) | 0.164 | |
Length of ICU stay (hours) | 48 (48, 60) | 47 (24, 54) | 0.276 | |
Length of Hospital stay (days) | 9 (8, 12) | 10.0 (8.25, 11) | 0.396 | |
28-day survival, n (%) | 31 (94.1) | 31 (100) | 0.164 | |