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Table 2 Clinical features for the patients with/without anti-infective therapy on ICU admission (day 0)

From: Epidemiology and prognosis of anti-infective therapy in the ICU setting during acute pancreatitis: a cohort study

 Missing dataAIT-free patients on day 0 n = 501Patients receiving AIT on day 0 n = 359p value
Male, n (%)0/5313 (62)239 (68)NS
Age, years, median [IQR]3/456 [43–71]60 [49–73]< 0.01
Clinical presentation on admission
 Pain onset/ICU admission interval, days, median [IQR]02 [1–4]4 [1–11]< 0.001
 Oliguria/anuria, n (%)0219 (44)154 (43)NS
 BISAP score, median [IQR]16/181 [0–1]2 [1–2]< 0.001
 Balthazar score E, n (%)0293 (58)200 (56)NS
Severity criteria on admission
 SOFA score, median [IQR]10/124 [2–6]5 [3–7]< 0.001
 Respiratory failure*, n (%)0109 (22)137 (38)< 0.001
 Cardiovascular failure*, n (%)077 (15)162 (45)< 0.001
 Renal failure*, n (%)090 (18)53 (15)NS
 Septic shock, n (%)07 (1)110 (31)< 0.001
 Acute respiratory distress syndrome, n (%)025 (5)37 (10)< 0.01
Therapeutic management on admission
 Vasoactive support, n (%)0/180 (16)165 (46)< 0.001
 Mechanical ventilation, n (%)1/595 (19)130 (37)< 0.001
 Fluid loading, n (%)2/12348 (70)277 (80)< 0.01
 Renal replacement therapy, n (%)1/1036 (7)42 (12)< 0.05
 Anti-infective therapy, n (%)0359 (100)< 0.001
Main treatments between day > 0 and day 30
 Need for red blood cell transfusion, n (%)0110 (22)116 (32)< 0.001
 Number of days of mechanical ventilation2/80 [0–9]2 [0–10]< 0.001
 Vasoactive support, n (%)0/1186 (37)208 (58)< 0.001
 Renal replacement therapy, n (%)2/0127 (25)93 (26)NS
 Duration of RRT, days, median [IQR]6/95 [2–14]5 [2–15]NS
Main complications between day > 0 and day 30
 Acute respiratory distress syndrome, n (%)0/2142 (28)99 (28)NS
 Septic shock, n (%)39/3290 (19)124 (38)0.001
 Pancreatic necrosis, n (%)13/17339 (69)218 (64)NS
 Infected necrosis, n (%)20/2488 (18)117 (35)< 0.001
 Gastro-intestinal perforation, n (%)20/2427 (6)27 (8)NS
 Vascular thrombosis, n (%)16/2255 (11)53 (16)NS
 Acute mesenteric ischaemia, n (%)18/2252 (11)36 (11)NS
 Intra-abdominal collection, n (%)14/18127 (26)152 (45)< 0.001
 Abdominal compartment syndrome, n (%)16/2252 (11)31 (9)NS
 Haemorrhage, n (%)16/2153 (11)47 (14)NS
 Peritonitis, n (%)19/2329 (6)59 (18)< 0.001
 Cholangitis, n (%)21/1918 (4)41 (12)< 0.001
 Digestive fistula, n (%)19/2111 (2)20 (6)< 0.01
Clinical management between day > 0 and day 30
 Endoscopic necrosectomy, n (%)3/589 (18)87 (25)< 0.05
 Surgical necrosectomy, n (%)1/5119 (24)132 (37)< 0.001
 Radiological drainage, n (%)1/556 (11)72 (20)< 0.001
Duration of ICU stay, days, median [IQR]06 [2–17]8 [3–21]< 0.05
ICU readmission n (%)0/130 (6)26 (7)NS
Hospital mortality rate, n (%)0104 (21)93 (26)NS
Time to death, days, median [IQR]03 [1–18]7 [1–31]NS
  1. NS non-significant, NA not applicable, AIT anti-infective therapy, ERCP endoscopic retrograde cholangiopancreatography
  2. *According to the definition of the SOFA score