Table 3 Comparison of outcomes of patients with high or low (cortisoltotal/CRP) ratio
Entire population | Placebo | Hydrocortisone treatment | |||||||
|---|---|---|---|---|---|---|---|---|---|
Low (cortisoltotal/ CRP) ratio | High (cortisoltotal/CRP) ratio | P values | Low (cortisoltotal/CRP) ratio | High (cortisoltotal/CRP) ratio | P values | Low (cortisoltotal/CRP) ratio | High (cortisoltotal/CRP) ratio | P values | |
Hospital-acquired pneumonia | 39 (39.39) | 50 (62.50) | 0.002 | 18 (37.50) | 32 (65.31) | 0.006 | 21 (41.18) | 18 (58.06) | 0.138 |
Pa02/Fi02 ratio | 146.5 [98–217] | 175.5 [133–232] | 0.147 | 164.5 [130–217] | 175.5 [133.5–246] | 0.581 | 122 [78–232.5] | 174 [132–227] | 0.156 |
Septic shock | 5 (12.82) | 2 (4.00) | 0.233 | 2 (11.11) | 0 | 0.125 | 3 (14.29) | 2 (11.11) | 1.00 |
Other infections | |||||||||
Meningitis | 2 (2.02) | 1 (1.25) | 1.000 | 1 (2.08) | 0 | 0.495 | 1 (1.96) | 1 (3.23) | 1.000 |
Urinary tract infection | 9 (9.09) | 11 (13.75) | 0.325 | 3 (6.25) | 10 (20.41) | 0.041 | 6 (11.76) | 1 (3.23) | 0.245 |
Bacteremia | 8 (8.08) | 5 (6.25) | 0.639 | 4 (8.33) | 3 (6.12) | 0.715 | 4 (7.84) | 2 (6.45) | 1.000 |
Organ failures | |||||||||
Duration of vasopressor support, days | 4 [3–6] | 4 [2–6] | 0.925 | 4 [3–6] | 5 (2–6] | 0.837 | 4 [3–5.5] | 4 [2–6] | 0.787 |
Acute respiratory distress syndrome | 18 (18.18) | 16 (20.00) | 0.758 | 5 (10.42) | 9 (18.37) | 0.265 | 13 (25.49) | 7 (22.58) | 0.766 |
Acute kidney injury | 0 | 1 (1.25) | 0.447 | 0 | 0 | – | 0 | 1 (3.23) | 0.378 |
SOFA day 1 | 9 [8–10] | 9 [7–10] | 0.592 | 9 [8–9.5] | 9 [7–10] | 0.877 | 9 [7–10] | 9 [7–10] | 0.511 |
SOFA day 3 | 8 [6–9] | 8 [5.5–9] | 0.706 | 8 [6–9] | 7 [5–9] | 0.383 | 8 [6–9] | 8 [6–10] | 0.658 |
SOFA day 7 | 4 [2–7] | 5 [4–6] | 0.398 | 4 [2.5–6.5] | 4 [4–6] | 0.352 | 5 [1–8] | 5 [4–6] | 0.810 |
Outcomes | |||||||||
Antibiotic-free days at day 28 | 21 [16–26] | 18.5 [11–21] | 0.007 | 21.5 [15.5–26.5] | 19 [12–21] | 0.225 | 21 [17–25] | 18 [11–22] | 0.52 |
Mean duration of mechanic ventilation (days) | 11 [7–20] | 13 [8–19.5] | 0.725 | 11.5 [7.5–18] | 12 [8–22] | 0.525 | 11 [7–25] | 13 [9–19] | 0.86 |
Mean duration of intensive care (days) | 15 [10–24] | 17 [11–28] | 0.288 | 16 [11–22] | 17 [12–28] | 0.167 | 15 [9–29] | 17 [10–28] | 0.867 |
Death in ICU | |||||||||
In-ICU death | 8 (8.01) | 9 (11.25) | 0.472 | 2 (4.17) | 5 (10.20) | 0.436 | 6 (11.76) | 4 (12.90) | 1.000 |