Temporal trends in the use of targeted temperature management after cardiac arrest and association with outcome: insights from the Paris Sudden Death Expertise Centre

Table 3 Factors associated with good neurological prognosis at ICU discharge in uni- and multivariate analysis in multiple imputation cohort (N = 3623 patients)

Characteristics	Univariate analysis		Multivariate analysis
Characteristics	Coefficient [95%CI]	P value	Coefficient [95%CI]	P value
Male	1.65 [1.39–1.97]	< 0.001	–	–
Age	0.97 [0.96–0.98]	< 0.001	0.96 [0.95–0.97]	< 0.001
Home location	0.32 [0.27–0.38]	< 0.001	0.59 [0.47–0.74]	< 0.001
Bystander CPR	2.62 [2.16–3.19]	< 0.001	1.65 [1.19–2.28]	0.003
Shockable rhythm	9.70 [8.04–11.70]	< 0.001	2.96 [2.29–3.93]	< 0.001
No flow > 3 min*	0.38 [0.32–0.45]	< 0.001	0.48 [0.36–0.64]	< 0.001
Low flow > 20 min*	0.21 [0.17–0.26]	< 0.001	0.50 [0.38–0.66]	< 0.001
Epinephrine use*	0.06 [0.05–0.08]	< 0.001	0.15 [0.11–0.19]	< 0.001
First arterial pH (by 0.1 unit)	1.86 [1.73–2.00]	< 0.001	1.31 [1.20–1.45]	< 0.001
Post-resuscitation shock	0.44 [0.37–0.42]	< 0.001	0.73 [0.57–0.94]	0.012
Early invasive coronary strategy	8.16 [6.50–10.25]	< 0.001	3.24 [2.37–4.43]	< 0.001
Targeted temperature management	2.71 [2.30–3.19]	< 0.001	1.57 [1.22–2.02]	< 0.001
Year of occurrence (2011 as reference)	1.01 [0.96–1.05]	0.75	–	–

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