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Table 3 Multivariate analysis for risk of non-recovery after acute kidney injury

From: Cumulative fluid accumulation is associated with the development of acute kidney injury and non-recovery of renal function: a retrospective analysis

Variables

MVR (variables pre-AKI)1

MVR (variables post-onset of AKI)2

OR

95% CI for OR

p value

OR

95% CI for OR

p value

Lower

Upper

Lower

Upper

AKI stage

    

1

  

< 0.001

AKI stage 2

    

0.63

0.31

1.28

0.21

AKI stage 3

    

2.24

1.16

4.31

0.02

SOFA score on admission to the ICU

1.05

0.96

1.15

0.26

    

SOFA score on the day of AKI/day 3

–

–

–

–

1.10

0.99

1.22

0.09

Lowest MAP on the day of AKI

–

–

–

–

0.99

0.96

1.02

0.36

Chronic kidney disease

2.01

1.12

3.58

0.02

2.82

1.37

5.78

0.01

Reason for admission: respiratory

1.52

0.94

2.45

0.09

    

Mechanical ventilation

2.29

1.24

4.26

0.01

4.34

2.05

9.15

< 0.001

Norepinephrine use

1.21

0.64

2.30

0.56

0.56

0.25

1.26

0.16

Vancomycin use

1.10

0.48

2.48

0.83

1.40

0.65

3.01

0.39

Diuretic use

1.89

1.20

2.97

0.01

    

Aminoglycoside use

1.13

0.69

1.83

0.63

    
  1. Model diagnostics:
  2. There was no evidence of lack of fit (Hosmer Lemeshow p = 0.217 and 0.248) that the model was incorrectly specified (link test p = 0.082 and 0.345) or of multicollinearity among the included covariates (all variance inflation factors < 3) for model MVR 1 or MVR 2
  3. AKI acute kidney injury, CI confidence interval, MAP mean arterial pressure, ICU intensive care unit, MVR multivariate analysis, NSAID non-steroidal anti-inflammatory drug, SOFA Sequential Organ Failure Assessment, OR odd ratio
  4. 1Also adjusted for the non-linear association between fluid balance and non-recovery (p < 0.001)
  5. 2Also adjusted for the non-linear association between net fluid balance and non-recovery (p = 0.016)
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Critical Care

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