Cumulative fluid accumulation is associated with the development of acute kidney injury and non-recovery of renal function: a retrospective analysis

Table 2 Multivariate analysis of risk factors for the development of new acute kidney injury

Variables	OR	95% CI for OR		p value
Variables	OR	Lower	Upper	p value
Age	1.00	1.00	1.01	0.24
BMI	1.06	1.04	1.07	<0.001
SOFA score on admission to the ICU	1.04	1.00	1.08	0.05
Lowest MAP	1.00	0.99	1.01	0.84
Sepsis	1.11	0.80	1.53	0.53
Chronic kidney disease	1.81	1.34	2.45	<0.001
Atherosclerotic cardiovascular disease	1.13	0.90	1.40	0.29
Congestive heart failure	1.12	0.81	1.56	0.50
Diabetes mellitus	1.06	0.85	1.33	0.60
Cancer	0.84	0.69	1.03	0.10
Mechanical ventilation	0.94	0.77	1.17	0.60
Norepinephrine use	1.20	0.94	1.54	0.15
NSAID use	0.48	0.22	1.05	0.07
Cumulative fluid balance on the day of AKI or day 3 in the ICU	1.11	1.08	1.14	<0.001

Model diagnostics:
There was no evidence of lack of fit (Hosmer Lemeshow p = 0.209) that the model was incorrectly specified (link test p = 0.300) or of multicollinearity among the included covariates (all variance inflation factors (VIF) < 1.5). There was no evidence of a non-linear relationship between cumulative fluid balance and AKI
BMI body mass index, CI confidence interval, MAP mean arterial pressure, NSAID non-steroidal anti-inflammatory drug, SOFA Sequential Organ Failure Assessment, OR odd ratio

ISSN: 1364-8535