Non-pulsatile blood flow is associated with enhanced cerebrovascular carbon dioxide reactivity and an attenuated relationship between cerebral blood flow and regional brain oxygenation

Table 2 Oxygenation, patient temperature and haemodynamics at the time of measurement

Flow mode PaCO₂ level	rSO₂ (%)	SaO₂ (%)	PaO₂ (mmHg)	Temp (°C)	MAP (mmHg)	CI (L/min/m²)
Non-pulsatile
30 mmHg	56 [51–60]	99 [98–100]	160 [140–177]	36.3 [35.9–36.7]	63 [57–68]	2.5 [2.4–2.7]
40 mmHg	59 [57–63]	99 [98–100]	170 [154–197]	36.4 [35.8–36.7]	63 [57–69]	2.5 [2.4–2.7]
50 mmHg	62 [57–66]	99 [98–100]	161 [133–190]	36.4 [35.9–36.7]	63 [54–68]	2.5 [2.3–2.7]
Pulsatile
30 mmHg	58 [56–64]	100* [99–100]	137* [116–161]	36.5 [36.3–36.7]	71* [66–80]	2.7 [2.1–3.3]
40 mmHg	61 [59–67]	100* [100–100]	140* [109–164]	36.4 [36.3–36.7]	72* [65–83]	2.6 [1.9–2.8]
50 mmHg	64 [62–70]	100* [99–100]	120* [101–146]	36.5 [36.3–36.7]	68* [65–75]	2.6 [2.0–3.3]

Values are medians [25th–75th percentile], rSO₂ Regional brain saturation, SaO₂ Arterial haemoglobin oxygen saturation, PaO₂ Arterial partial pressure of oxygen, Temp patient temperature MAP mean arterial blood pressure, CI cardiac index (n = 8), * = p < 0.05 vs. corresponding value during non-pulsatile flow (ANOVA with post hoc Tukey test)

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