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Table 3 Gene expression changes in inflammatory pathway, pattern recognition receptors, and DNA replication

From: A longitudinal study highlights shared aspects of the transcriptomic response to cardiogenic and septic shock

Gene nameCategoryMolecular functionCS_log2FC_T1T3SS_log2FC_T1T2
BCL6InflammationTranscription factor− 0.68− 0.58
CCR1InflammationChemokine receptor− 0.67− 0.61
CD55InflammationRegulation of complement cascade− 0.77− 1.00
CEBPBInflammationTranscription factor− 0.63− 0.79
CYP19A1InflammationAromatase—estrogen synthesis− 1.28− 1.23
EDNRBInflammationEndothelin receptor− 0.79− 0.90
FCER1GInflammationAntibody receptor− 0.55− 0.80
FLOT1InflammationVesicle trafficking and cell morphology− 0.60− 0.77
IL10RBInflammationInterleukin receptor− 0.48− 0.50
IL17RAInflammationInterleukin receptor− 0.47− 0.35
IL4RInflammationInterleukin receptor− 0.58− 0.82
MAPK14InflammationMAPK p38− 0.58− 0.75
NAIPInflammationInflammosome− 0.63− 0.80
NLRC4InflammationInflammosome− 0.63− 0.73
PPARGInflammationTranscription factor− 1.07− 0.78
PTPN22InflammationTyrosine phosphatase− 0.43− 0.65
RBPJInflammationTranscription factor− 0.61− 0.34
RELInflammationNF-KB subunit− 0.36− 0.29
S100A12InflammationAlarmin− 0.71− 1.17
S100A8InflammationAlarmin− 0.60− 0.78
S100A9InflammationAlarmin− 0.53− 0.54
SBNO2InflammationTranscriptional regulation of NF-kappaB− 0.56− 0.38
STAT3InflammationTranscription factor− 0.42− 0.43
UBCInflammationPolyubiquitin precursor− 0.38− 0.26
VAMP3InflammationVesicular transport− 0.35− 0.46
VNN1InflammationLeucocyte adhesion and migration− 0.67− 0.97
CLEC5APattern recognition receptorC-type lectin receptor− 0.63− 1.42
CLEC6APattern recognition receptorC-type lectin receptor− 0.75− 1.07
IRAK3Pattern recognition receptorPRR downstream signaling− 0.78− 0.51
TLR1Pattern recognition receptorToll-like receptor− 0.58− 0.39
TLR4Pattern recognition receptorToll-like receptor− 0.74− 0.53
TLR8Pattern recognition receptorToll-like receptor− 0.66− 0.44
DNAJA3DNA replicationInteractor of DNA polymerase0.410.34
FEN1DNA replicationDNA replication and repair0.830.59
GINS2DNA replicationDNA replication initiation1.180.79
HIST1H4IDNA replicationReplication-dependent histone0.530.57
MCM2DNA replicationMCM complex0.880.76
MCM3DNA replicationMCM complex0.540.60
MCM5DNA replicationMCM complex0.360.36
MCM7DNA replicationMCM complex0.480.55
RRM1DNA replicationBiosynthesis of deoxyribonucleotides0.430.36
RUVBL1DNA replicationDNA helicase0.510.37
  1. Genes with significant modulation over time in both CS and SS, but not in SC. Description of functions and log2FoldChange expression are shown