A longitudinal study highlights shared aspects of the transcriptomic response to cardiogenic and septic shock

Braga, Daniele; Barcella, Matteo; Herpain, Antoine; Aletti, Federico; Kistler, Erik B.; Bollen Pinto, Bernardo; Bendjelid, Karim; Barlassina, Cristina

doi:10.1186/s13054-019-2670-8

Critical Care

Table 3 Gene expression changes in inflammatory pathway, pattern recognition receptors, and DNA replication

From: A longitudinal study highlights shared aspects of the transcriptomic response to cardiogenic and septic shock

Gene name	Category	Molecular function	CS_log₂FC_T1T3	SS_log₂FC_T1T2
BCL6	Inflammation	Transcription factor	− 0.68	− 0.58
CCR1	Inflammation	Chemokine receptor	− 0.67	− 0.61
CD55	Inflammation	Regulation of complement cascade	− 0.77	− 1.00
CEBPB	Inflammation	Transcription factor	− 0.63	− 0.79
CYP19A1	Inflammation	Aromatase—estrogen synthesis	− 1.28	− 1.23
EDNRB	Inflammation	Endothelin receptor	− 0.79	− 0.90
FCER1G	Inflammation	Antibody receptor	− 0.55	− 0.80
FLOT1	Inflammation	Vesicle trafficking and cell morphology	− 0.60	− 0.77
IL10RB	Inflammation	Interleukin receptor	− 0.48	− 0.50
IL17RA	Inflammation	Interleukin receptor	− 0.47	− 0.35
IL4R	Inflammation	Interleukin receptor	− 0.58	− 0.82
MAPK14	Inflammation	MAPK p38	− 0.58	− 0.75
NAIP	Inflammation	Inflammosome	− 0.63	− 0.80
NLRC4	Inflammation	Inflammosome	− 0.63	− 0.73
PPARG	Inflammation	Transcription factor	− 1.07	− 0.78
PTPN22	Inflammation	Tyrosine phosphatase	− 0.43	− 0.65
RBPJ	Inflammation	Transcription factor	− 0.61	− 0.34
REL	Inflammation	NF-KB subunit	− 0.36	− 0.29
S100A12	Inflammation	Alarmin	− 0.71	− 1.17
S100A8	Inflammation	Alarmin	− 0.60	− 0.78
S100A9	Inflammation	Alarmin	− 0.53	− 0.54
SBNO2	Inflammation	Transcriptional regulation of NF-kappaB	− 0.56	− 0.38
STAT3	Inflammation	Transcription factor	− 0.42	− 0.43
UBC	Inflammation	Polyubiquitin precursor	− 0.38	− 0.26
VAMP3	Inflammation	Vesicular transport	− 0.35	− 0.46
VNN1	Inflammation	Leucocyte adhesion and migration	− 0.67	− 0.97
CLEC5A	Pattern recognition receptor	C-type lectin receptor	− 0.63	− 1.42
CLEC6A	Pattern recognition receptor	C-type lectin receptor	− 0.75	− 1.07
IRAK3	Pattern recognition receptor	PRR downstream signaling	− 0.78	− 0.51
TLR1	Pattern recognition receptor	Toll-like receptor	− 0.58	− 0.39
TLR4	Pattern recognition receptor	Toll-like receptor	− 0.74	− 0.53
TLR8	Pattern recognition receptor	Toll-like receptor	− 0.66	− 0.44
DNAJA3	DNA replication	Interactor of DNA polymerase	0.41	0.34
FEN1	DNA replication	DNA replication and repair	0.83	0.59
GINS2	DNA replication	DNA replication initiation	1.18	0.79
HIST1H4I	DNA replication	Replication-dependent histone	0.53	0.57
MCM2	DNA replication	MCM complex	0.88	0.76
MCM3	DNA replication	MCM complex	0.54	0.60
MCM5	DNA replication	MCM complex	0.36	0.36
MCM7	DNA replication	MCM complex	0.48	0.55
RRM1	DNA replication	Biosynthesis of deoxyribonucleotides	0.43	0.36
RUVBL1	DNA replication	DNA helicase	0.51	0.37

Genes with significant modulation over time in both CS and SS, but not in SC. Description of functions and log₂FoldChange expression are shown

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ISSN: 1364-8535

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