Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 1 Characteristics of included studies

From: A meta-analysis of the effects of therapeutic hypothermia in adult patients with traumatic brain injury

StudyPopulationAgeGCSInduction timeTarget temperatureHypothermia durationRewarming rateFollow-up time
HTCONHTCON
Aibiki et al. [19]151134 ± 638 ± 8≤ 83–4 h32–33 °C3–4 days1 °C/day6 months
Andrews et al. [2]19519237.4 ± 15.436.7 ± 14.93–153–10 days32–35 °C48 h0.25 °C/h6 months
Clifton et al. [15]2422NMNM4–76 h32–33 °C48 h1 °C/4 hNM
Clifton et al. [21]19017831 ± 1232 ± 133–86 h32.5–34.0 °C48 h0.5 °C/2 h6 months
Clifton et al. [31]524526 ± 931 ± 113–82.5 h33 °C48 h0.5 °C/2 h6 months
Cooper et al. [8]25623935 ± 13.534.1 ± 13.4< 9Rapidly33 ± 0.5 °C72 h0.25 °C/h6 months
Harris et al. [30]121338.1 ± 1533.2 ± 20≤ 824 h33 °C24 h0.5 °C/3 hNM
Hashiguchi et al. [23]9829.0 ± 14.939.1 ± 13.2< 8As soon as possible33.5–34.5 °C48 h1 °C/day6 months
Idris et al. [34]91317.3–40.535.0–56.16–7NM20–29 °C, 30–36 °C24–48 hNM6 months
Jiang et al. [20]4344Mean 42.2Mean 40.6≤ 815 h33–35 °C3–14 days≤ 1 °C/h12 months
Liu et al. [28]4323NMNM≤ 82 h33–35 °C3 daysPassive24 months
Maekawa et al. [32]944539 ± 1939 ± 184–892 h32–34 °C≥ 72 h< 1 °C/day6 months
Marion et al. [17]404231 ± 1235 ± 153–710 h32–33 °C24 hPassive12 months
Meissner et al. [24]1113Median 30Median 48≤ 98 h32–33 °C24–48 hNMNM
Qiu et al. [26]4343Mean 40.0Mean 42.3< 84.3 days33–35 °C3–5 daysPassive24 months
Qiu et al. [29]4040Mean 41.3Mean 40.2≤ 8Immediately33–35 °C4 daysPassive12 months
Shiozaki et al. [16]161735.3 ± 15.335.4 ± 12.6≤ 824 h33.5–34.5 °C2 daysPassive6 months
Shiozaki et al. [18]8831.4 ± 12.740.3 ± 23.1≤ 82 h33.5–34.5 °C48 h1 °C/day6 months
Shiozaki et al. [22]454635 ± 2042 ± 17≤ 8As quickly as possible33.5–34.5 °C48 h1 °C/day3 months
Smrcka et al. [27]3537NMNM< 815 h34 °C72 hPassive6 months
Tang et al. [33]303042.47 ± 13.9339.67 ± 15.263–8Within 24 h32–35 °C48 h0.25 °C/h6–48 months
Zhao et al. [6]404136.9 ± 14.837.5 ± 15.23–83–5 h32.5–33 °C72 hPassive3 months
Zhi et al. [25]19819843 ± 1742 ± 19≤ 8Within 24 h32–35 °C1–7 days1 °C/4 h6 months
  1. HT therapeutic hypothermia, CON control, GCS Glasgow Coma Score, NM not mentioned