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Table 3 Comparative prognostic performance for 90-day mortality of the less than 25% SOFA decrease cutoff on day 7 ΔSOFA between the derivation and validation cohorts

From: The early change of SOFA score as a prognostic marker of 28-day sepsis mortality: analysis through a derivation and a validation cohort

 Derivation cohort (95% CI)Validation cohort (95% CI)p value
Sensitivity74.6% (69.5–83.4)77.1% (69.5–83.4)0.63
Specificity81.8% (77.1–85.7)47.8% (33.1–62.9)2.00 × 10−5
PPV59.5% (51.1–67.4)83.1% (75.7–88.7)9.00 × 10−5
NPV90.0% (85.9–93.1)38.6% (26.3–52.4)1.54 × 10−27
  1. Abbreviations: CI confidence interval, NPV negative predictive value, PPV positive predictive value