Table 1 The criteria for assessment of the Sequential Organ Failure Assessment (SOFA) score
From: The SOFA score—development, utility and challenges of accurate assessment in clinical trials
Respiratory system | |
PaO2/FiO2 (mmHg) | SOFA score |
> 400 | 0 |
< 400 | 1 |
< 300 | 2 |
< 200 with respiratory support | 3 |
< 100 with respiratory support | 4 |
Nervous system | |
Glasgow Coma Scale | SOFA score |
15 | 0 |
13–14 | 1 |
10–12 | 2 |
6–9 | 3 |
< 6 | 4 |
Cardiovascular system | |
Mean arterial pressure (MAP) OR administration of vasopressors required | SOFA score |
MAP > 70 mmHg | 0 |
MAP < 70 mm/Hg | 1 |
Dopamine ≤ 5 μg/kg/min or dobutamine (any dose) | 2 |
Dopamine > 5 μg/kg/min OR epinephrine ≤ 0.1 μg/kg/min OR norepinephrine ≤ 0.1 μg/kg/min | 3 |
Dopamine > 15 μh/kg/min OR epinephrine > 0.1 μg/kg/min OR norepinephrine > 0.1 μg/kg/min | 4 |
Liver | |
Bilirubin (mg/dl) [μmol/L] | SOFA score |
< 1.2 (< 20) | 0 |
1.2–1.9 [20–32] | 1 |
2.0–5.9 [33–101] | 2 |
6.0–11.9 [102–204] | 3 |
> 12.0 [> 204] | 4 |
Coagulation | |
Platelets ×103/ml | SOFA score |
> 150 | 0 |
< 150 | 1 |
< 100 | 2 |
< 50 | 3 |
< 20 | 4 |
Kidneys | |
Creatinine (mg/dl) [μmol/L]; urine output | SOFA score |
< 1.2 [< 110] | 0 |
1.2–1.9 [110–170] | 1 |
2.0–3.4 [171–299] | 2 |
3.5–4.9 [300–440] (or urine output < 500 ml/day) | 3 |
> 5.0 [> 440]; urine output < 200 ml/day | 4 |