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Table 1 Baseline characteristics and outcome

From: Extracorporeal membrane oxygenation in Pneumocystis jirovecii pneumonia: outcome in HIV and non-HIV patients

 

All (n = 18)

HIV (n = 6)

non-HIV (n = 12)

p value

Age (years)

49.7 ± 18.4

36.8 ± 9.7

56.2 ± 18.6

0.032

Sex (male)

11 (61.1%)

4 (66.7%)

7 (58.3%)

1.0

BMI (kg/m2)

24.6 ± 3.4

23.0 ± 4.2

25.5 0 ± 2.6

0.149

Underlying pulmonary disease*

2 (11.1%)

0 (0%)

2 (16.7%)

0.407

Comorbidities

 Hypertension

5 (27.8%)

0 (0%)

5 (41.27%)

0.114

 Renal insufficiency

2 (11.1%)

0 (0%)

2 (16.7%)

0.529

 Chronic haemodialysis

1 (5.6%)

0 (0%)

1 (8.3%)

1.0

MV pre-ECMO

 PEEP (mbar)

14.9 ± 3.1

13.8 ± 2.9

15.3 ± 3.2

0.489

 Plateau pressure (mbar)

28.5 ± 4.6

29.3 ± 4.0

28.2 ± 4.9

0.571

 Driving pressure (mbar)

13.6 ± 4.2

15.5 ± 4.5

12.9 ± 4.1

0.412

 Tidal volume (ml)

390.7 ± 107.9

362.5 ± 104.4

400.9 ± 112.3

0.571

 Minute volume (l/min)

9.9 ± 3.6

10.6 ± 4.3

9.6 ± 3.5

0.571

 Compliance (ml/mbar)

32.7 ± 15.8

23.3 ± 10.4

35.5 ± 17.0

0.226

 FiO2 (%)

83.8 ± 19.4

87.5 ± 19.4

81.8 ± 19.4

0.660

 Horowitz index (mmHg)

87.6 ± 37.6

90.8 ± 40.8

85.8 ± 37.6

1.0

 D(A-a)O2 (mmHg)

466.4 ± 133.4

481.7 ± 132.9

458.1 ± 139.4

0.884

MV duration before ECMO (days)

5.4 ± 5.4

9.3 ± 6.5

3.3 ± 3.3

0.048

Acute renal failure

3 (16.7%)

0 (0%)

3 (25.0%)

0.276

LDHmax (U/l) before ECMO

734.1 ± 268.2

577.2 ± 182.1

812.5 ± 275.5

0.083

Scores

 SOFA score

9.7 ± 3.6

8.7 ± 3.4

10.3 ± 3.7

0.733

 APACHE II score

24.9 ± 8.1

25.0 ± 9.0

24.9 ± 8.1

0.961

 RESP score

− 3.3 ± 3.2

− 2.8 ± 1.9

− 3.55 ± 3.8

1.0

Successful ECMO weaning

7 (38.9%)

3 (50%)

4 (33.3%)

0.494

Survival

4 (22.2%)

3 (50%)

1 (8.3%)

0.045

ICU length of stay (days)

26.2 ± 20.5

33.8 ± 15.4

22.4 ± 22.3

0.053

ECMO duration (days)

13.2 ± 8.7

13.8 ± 11.0

12.9 ± 7.8

0.892

MV duration (days)

20.8 ± 14.8

25.2 ± 17.1

18.4 ± 13.7

0.462

Acute haemodialysis

6 (33.3%)

0 (0%)

6 (50.0%)

0.054

Prone position while ECMO

11 (61.1%)

5 (83.3%)

6 (50.0%)

0.588

  1. ICU intensive care unit, MV mechanical ventilation
  2. *Underlying pulmonary disease: lung fibrosis (n = 2)
  3. ICU and hospital survival