Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 2 Comparison of meta-analyses. Results from meta-analyses before and after the two recent landmark trials on saline versus balanced crystalloids in the setting of intensive care medicine and emergency medicine. For reference, information from two large ongoing trials on this topic has also been included

From: Why physiology will continue to guide the choice between balanced crystalloids and normal saline: a systematic review and meta-analysis

 Meta-analysesCurrent meta-analysisLandmark trialsOngoing trials
First author, yearSerpa, 2017 [29]Kawano, 2018 [13]Zayed, 2018 [14]Liu, 2019 [18]Xue, 2019 [17]Xue, 2019 [17]Xue, 2019 [17]ZwagerZwagerZwagerZwagerSemler, 2018 [15]Self, 2018 [16]BASICSPLUS
Setting or type of sensitivity analysisICUICU/ORICUICUICUSepsisTBIICUEDSepsisTBIICUEDICUICU
n23483710226920345193012420142063501457187312191580213347110008800
Analysis
 Adjusted for design effect?NoNoNoNoNoNoNoYesYesYesYes
Mortality (balanced crystalloids, %)7.548.9111.5010.3310.1224.8315.2111.371.6533.0515.2111.681.40  
Mortality (normal saline, %)8.579.6112.2013.1710.9328.9613.7712.102.0637.9514.1412.401.54  
Risk ratio0.880.900.940.930.920.861.110.940.830.871.080.940.90  
P value for risk ratio0.360.440.100.080.060.020.430.360.620.020.580.100.43  
RRR (%)0.120.100.060.070.080.14− 0.110.060.170.13− 0.080.060.10  
Assumed baseline mortality (%) 30.00 13.2010.9329.00 12.102.0637.9514.14  35.0023.00
Assumed RRR (%) 10.00 10.006.4214.48 5.005.005.005.00  10.0012.50
Alpha (%) 5 555 5555  55
Power (%) 80 909090 90909090  8990
Required information size (RIS) 9517 26456809464686 1175148278172713999090  110008800
Accrued information size (AIS) 3710 20345193012420 6350145718731219    
AIS/RIS 0.39 0.770.240.52 0.050.0020.070.01    
  1. RRR relative risk reduction, RIS required information size, AIS accrued information size