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Table 1 Characteristics of included studies

From: Why physiology will continue to guide the choice between balanced crystalloids and normal saline: a systematic review and meta-analysis

First author, yearTotal number of patientsSettingType of balanced crystalloidMortality: follow-up period in daysRRT: follow-up period in daysAKI classification (follow-up period in days)Cumulative volume of fluids in litres, mean ± SD, median (IQR)
ICU-based studies
 Young, 2014 [5]65ED and ICUPlasma-Lyte A30AKIN (5)-NS, 9.0 ± 5.5
-Balanced, 10.3 ± 6.5
 Young, 2015 [6]2278ICUPlasma-LyteIn hospital90KDIGO ≥ II (90)-NS, 2.0 (1.0–3.3)
-Balanced, 2.0 (1.0–3.5)
 Verma, 2016 [8]70ICUPlasma-LyteIn hospitalIn hospitalRIFLE Injury and Failure (4)-NS, 3.4 (1.2–5.8)
-Balanced, 2.9 (1.6–5.6)
 Ratanarat, 2017 [27]181ICUSterofundinKDIGO (7)-NS, 11.2
-Balanced, 11.2
 Semler, 2017 [11]974ICULR or Plasma-Lyte A6028KDIGO ≥ II (30)-NS, 1.4 (0.5–3.4)
-Balanced, 1.6 (0.5–3.6)
 Semler, 2018 [15]15,802ICULR or Plasma-Lyte A6028KDIGO ≥ II (after enrolment)-NS, 1.02 (0–3.5)
-Balanced, 1 (0–3.21)
Included ED-based studies
 Van Zyl, 2012 [7]51EDLRIn hospitalNot stated
 Young, 2014 [5]65ED and ICUPlasma-Lyte A30AKIN (5)-NS, 9.0 ± 5.5
-Balanced, 10.3 ± 6.5
 Self, 2018 [16]13,347EDLR or Plasma-Lyte AIn hospital30KDIGO ≥ II (30)-NS, 1.07 (1–2)
-Balanced, 1.08 (1–2)
 Choosakul, 2018 [28]47EDLRIn hospital-NS, 5.4 ± 0.8
-Balanced, 4.9 ± 1.3
  1. ED emergency department, ICU intensive care unit, LR lactated Ringer’s, RRT renal replacement therapy, AKI acute kidney injury, NS normal saline, SD standard deviation, IQR interquartile range