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Fig. 4 | Critical Care

Fig. 4

From: Why physiology will continue to guide the choice between balanced crystalloids and normal saline: a systematic review and meta-analysis

Fig. 4

Trial sequential analysis for mortality for the setting of intensive care medicine based on the DerSimonian-Laird random effects model and the O’Brien-Fleming alpha spending function, using estimates of 12.10% for baseline mortality, 5% for relative risk reduction, 5% for alpha and 90% for power. For the setting of emergency medicine, assuming a baseline mortality of 2.06%, no alpha spending boundaries could be calculated because of too small accrued information size

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Critical Care

ISSN: 1364-8535