Respective contribution of intensive care unit-acquired limb muscle and severe diaphragm weakness on weaning outcome and mortality: a post hoc analysis of two cohorts

Table 2 Main clinical outcomes according to the presence of severe intensive care unit-acquired diaphragm dysfunction (S-ICU-DD) and intensive care unit-acquired weakness (ICU-AW)

	No S-ICU-DD		S-ICU-DD		p
	No weakness	ICU-AW	No weakness	ICU-AW	p
N	36 (31%)	32 (28%)	14 (12%)	34 (29%)
Outcomes
SBT failure, n (%)	7 (19)	14 (44)*	7 (58)*	26 (72)*^#	< 0.0001
Reintubation after extubation following successful SBT, n (%)	3 (8)	6 (19)*	1 (8)	8 (23)*	0.039
Weaning failure, n (%)	10 (28)	20 (63)*	8 (67)*	31 (86)*^#	< 0.0001
MV until extubation, days	4 (1–6)	7 (4–13)*	7 (3–8)	13 (7–24)*	< 0.0001
ICU length of stay, days	5 (3–14)	15 (7–30)*	9 (4–13)^#	20 (9–30)*^†	< 0.0001
ICU mortality, n (%)	3 (8)	4 (13)	0 (0)	14 (39)*^#†	0.001

Data are expressed as median (interquartile range) or n (%)
SBT spontaneous breathing trial, MV mechanical ventilation, ICU intensive care unit
*vs. No S-ICU-DD–No ICU-AW
^#vs. No S-ICU-DD–ICU-AW
^†vs. S-ICU-DD–No ICU-AW

ISSN: 1364-8535