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Table 1 Characteristics of the study population on intensive care unit admission according to the presence of severe intensive care unit-acquired diaphragm dysfunction (S-ICU-DD) and intensive care unit-acquired weakness (ICU-AW)

From: Respective contribution of intensive care unit-acquired limb muscle and severe diaphragm weakness on weaning outcome and mortality: a post hoc analysis of two cohorts

  No S-ICU-DD S-ICU-DD p
No weakness ICU-AW No weakness ICU-AW
N 36 (31%) 32 (28%) 14 (12%) 34 (29%)  
Demographic data
 Men, n (%) 27 (75) 19 (59) 7 (58) 24 (71) 0.522
 Age, years 58 (40–55) 56 (50–65) 70 (50–78)* 64 (56–75)*# 0.009
 Body mass index, kg/m2 24 (21–27) 23 (21–26) 24 (20–33) 25 (22–29) 0.302
Medical conditions
 COPD, n (%) 7 (19) 0 (0)* 3 (21)# 7 (21) # 0.049
 Heart failure, n (%) 7 (19) 2 (6) 2 (14) 6 (18) 0.453
Reason for ICU admission
 Shock 11 (33) 10 (31) 3 (21) 13 (38) 0.793
 Coma 13 (39) 5 (19) 3 (21) 6 (18) 0.186
 Acute respiratory failure 12 (33) 17 (53) 8 (57) 15 (44) 0.387
On admission
 SOFA 4 (3–5) 7 (4–10)* 6 (5–8)* 8 (5–13)* < 0.0001
 Sepsis, n (%) 24 (67) 23 (72) 7 (58) 23 (68) 0.830
At inclusion
 MV prior to inclusion, days 3 (1–5) 4 (4–9) 5 (1–7)* 9 (5–15)* < 0.0001
 Medication exposure      
 Neuromuscular blocker, n (%) 4 (11) 13 (41)* 4 (28) 17 (50)* 0.017
 Corticosteroids, n (%) 1 (3) 3 (9) 4 (28)* 1 (3) < 0.0001
 Norepinephrine, n (%) 9 (25) 21 (66)* 3 (21)# 30 (88)* < 0.0001
 Midazolam, n (%) 11 (31) 16 (50) 5 (36) 13 (38) 0.346
 Propofol (%) 23 (64) 5 (19)* 7 (50)# 5 (15)* < 0.0001
 Sufentanil, n (%) 16 (44) 21 (66) 7 (50) 31 (91)* †# 0.001
Muscle assessment
 Ptr,stim, cmH2O 10.9 (7.9–15.3) 11.0 (9.0–14.0) 5.0 (4.1–6.3)*# 3.5 (2.4–6.3)*# < 0.0001
 MRC score 56 (51–59) 35 (23–43)* 55 (51–57)# 33 (24–40)* < 0.0001
  1. Data are expressed as median (interquartile range) or n (%)
  2. COPD chronic obstructive pulmonary disease, SOFA Sequential Organ Failure Assessment, MV mechanical ventilation, Ptr,stim endotracheal tube pressure induced by bilateral phrenic nerve stimulation during airway occlusion, MRC Medical Research Council
  3. *vs. No S-ICU-DD–No ICU-AW
  4. #vs. No S-ICU-DD–ICU-AW
  5. vs. S-ICU-DD–No ICU-AW