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Table 1 Characteristics of the study population on intensive care unit admission according to the presence of severe intensive care unit-acquired diaphragm dysfunction (S-ICU-DD) and intensive care unit-acquired weakness (ICU-AW)

From: Respective contribution of intensive care unit-acquired limb muscle and severe diaphragm weakness on weaning outcome and mortality: a post hoc analysis of two cohorts

 

No S-ICU-DD

S-ICU-DD

p

No weakness

ICU-AW

No weakness

ICU-AW

N

36 (31%)

32 (28%)

14 (12%)

34 (29%)

 

Demographic data

 Men, n (%)

27 (75)

19 (59)

7 (58)

24 (71)

0.522

 Age, years

58 (40–55)

56 (50–65)

70 (50–78)*

64 (56–75)*#

0.009

 Body mass index, kg/m2

24 (21–27)

23 (21–26)

24 (20–33)

25 (22–29)

0.302

Medical conditions

 COPD, n (%)

7 (19)

0 (0)*

3 (21)#

7 (21) #

0.049

 Heart failure, n (%)

7 (19)

2 (6)

2 (14)

6 (18)

0.453

Reason for ICU admission

 Shock

11 (33)

10 (31)

3 (21)

13 (38)

0.793

 Coma

13 (39)

5 (19)

3 (21)

6 (18)

0.186

 Acute respiratory failure

12 (33)

17 (53)

8 (57)

15 (44)

0.387

On admission

 SOFA

4 (3–5)

7 (4–10)*

6 (5–8)*

8 (5–13)*

< 0.0001

 Sepsis, n (%)

24 (67)

23 (72)

7 (58)

23 (68)

0.830

At inclusion

 MV prior to inclusion, days

3 (1–5)

4 (4–9)

5 (1–7)*

9 (5–15)*

< 0.0001

 Medication exposure

     

 Neuromuscular blocker, n (%)

4 (11)

13 (41)*

4 (28)

17 (50)*

0.017

 Corticosteroids, n (%)

1 (3)

3 (9)

4 (28)*

1 (3)

< 0.0001

 Norepinephrine, n (%)

9 (25)

21 (66)*

3 (21)#

30 (88)*

< 0.0001

 Midazolam, n (%)

11 (31)

16 (50)

5 (36)

13 (38)

0.346

 Propofol (%)

23 (64)

5 (19)*

7 (50)#

5 (15)*

< 0.0001

 Sufentanil, n (%)

16 (44)

21 (66)

7 (50)

31 (91)* †#

0.001

Muscle assessment

 Ptr,stim, cmH2O

10.9 (7.9–15.3)

11.0 (9.0–14.0)

5.0 (4.1–6.3)*#

3.5 (2.4–6.3)*#

< 0.0001

 MRC score

56 (51–59)

35 (23–43)*

55 (51–57)#

33 (24–40)*

< 0.0001

  1. Data are expressed as median (interquartile range) or n (%)
  2. COPD chronic obstructive pulmonary disease, SOFA Sequential Organ Failure Assessment, MV mechanical ventilation, Ptr,stim endotracheal tube pressure induced by bilateral phrenic nerve stimulation during airway occlusion, MRC Medical Research Council
  3. *vs. No S-ICU-DD–No ICU-AW
  4. #vs. No S-ICU-DD–ICU-AW
  5. vs. S-ICU-DD–No ICU-AW