Table 5 Characteristics and outcomes comparing patients with mono- versus polymicrobial Stenotrophomonas maltophilia HAPs
Variables | Sm only N = 117 | Polymicrobial Sm HAP N = 164 | p value |
|---|---|---|---|
Gender, male | 78 (66.7) | 119 (72.6) | 0.362 |
Age, years | 67 [59–76] | 64 [55–72] | 0.024 |
BMI (kg m−2) | 24.6 [21.1–29.6] | 25.7 [22.3–28.4] | 0.361 |
Reason for ICU admission | 0.024 | ||
Medical condition | 80 (68.4) | 87 (53) | |
Scheduled surgery | 8 (6.8) | 24 (14.6) | |
Emergent surgery | 29 (24.8) | 53 (32.3) | |
Previous carriage of S. maltophilia | 5 (4.3) | 6 (3.7) | 0.812 |
Pulmonary comorbidities | |||
Chronic obstructive pulmonary disease | 27 (23.1) | 24 (14.6) | 0.084 |
Chronic respiratory insufficiency | 15 (12.8) | 14 (8.5) | 0.245 |
Cystic fibrosis | 0 (0) | 2 (1.2) | 0.512 |
Prior exposure to carbapenems | 27 (23.1) | 37 (22.5) | 0.723 |
Susceptibility to trimethoprim–sulfamethoxazole | 97 (82.9) | 147 (89.6) | 0.424 |
Severity scores | |||
SOFA score at admission | 8 [5–11] | 8 [5–11] | 0.381 |
SAPS II at 24 h | 48 [37–62] | 47 [36–63] | 0.672 |
Ventilator-associated pneumonia | 91 (77.8) | 136 (82.9) | 0.280 |
Duration of mechanical ventilation prior to S. maltophilia HAP, days | 9 [2–17] | 11 [6–20] | 0.031 |
ICU length of stay, days | 28 [16–49] | 36 [22–60] | 0.034 |
Hospital length of stay, days | 45 [26–80] | 59 [32–98] | 0.062 |
Number of days between hospital admission and S. maltophilia HAP | 14 [8–23] | 17 [8–31] | 0.294 |
Number of days between ICU admission and S. maltophilia HAP | 10 [5–18] | 12 [6–20] | 0.046 |
Empiric antibiotic therapy | 67 (57.3) | 99 (60.4) | 0.602 |
Combination therapy active on S. maltophilia | 66 (56.4) | 100 (61.0) | 0.407 |
Overall in-hospital mortality | 63 (53.8) | 74 (45.1) | 0.228 |
In-hospital mortality according to empiric antimicrobial therapy | 0.273 | ||
Appropriate | 8 (6.8) | 16 (9.8) | |
Inappropriate | 24 (20.5) | 30 (18.3) | |