Table 1 Patients’ characteristics in our study population with CDI stratified according to 28-day mortality
Parameter | All patients with CDI n = 132 | 28-day survivors n = 96 | 28-day non-survivors n = 36 | p |
|---|---|---|---|---|
Number of patients, n (%) | 132 (100) | 96 (72.2) | 36 (27.3) | |
Age in years (median, IQR25–75) | 70 (59–77) | 70.5 (59–75) | 70 (59–79) | 0.347 |
Male, n (%) | 94 (71.2) | 69 (71.8) | 25 (69.4) | 0.784 |
Weight (kg) (median, IQR25–75) | 75 (65–83) | 75 (67–83) | 70 (63–81) | 0.123 |
Height (cm) (median, IQR25–75) | 172 (165–180) | 172 (165–180) | 171 (164–176) | 0.185 |
Charlson Comorbidity Index (median, IQR25–75) | 5 (3–7) | 5 (3–7) | 5.5 (4–8) | 0.125 |
SAPS on admission (median, IQR25–75) | 41 (33–50) | 38.5 (31–48) | 44.5 (38–55) | 0.003* |
TISS28 on admission (median, IQR25–75) | 10 (9–17) | 14 (9–19) | 10 (8–13.5) | 0.233 |
SOFA Score on admission (median, IQR25–75) | 6 (4–9) | 6.5 (4–9) | 6 (4–9) | 0.472 |
SOFA Score on diagnosis (median, IQR25–75) | 4 (2–6) | 4 (2–6) | 6 (4–9) | 0.001* |
Diagnoses | ||||
Principal diagnosis C. difficile infection (CDI), n (%) | 5 (3.8) | 2 (2.1) | 3 (8.3) | 0.094 |
Principal diagnosis non CDI-related sepsis, n (%) | 40 (30.3) | 22 (22.9) | 18 (50) | 0.003* |
Principal diagnosis postoperative, n (%) | 39 (29.5) | 31 (32.3) | 8 (22.2) | 0.259 |
Principal diagnosis heart failure, n (%) | 22 (16.7) | 16 (16.7) | 6 (16.7) | 1.000 |
Principal diagnoses, others, n (%)* | 36 (27.3) | 31 (32.3) | 5 (13.9) | 0.034* |
Neutropenia, n (%) | 8 (6.1) | 3 (3.1) | 5 (13.9) | 0.021* |
Treatment | ||||
Mechanical ventilation overall, n (%) | 96 (72.7) | 66 (68.8) | 30 (83.3) | 0.094 |
Vasopressor therapy on admission, n (%) | 104 (78.8) | 72 (75) | 32 (88.9) | 0.082 |
Renal replacement therapy (RRT), n (%) | 32 (24.2) | 15 (15.6) | 17 (47.2) | < 0.001* |
Parenteral nutrition on diagnosis, n (%) | 27 (20.5) | 15 (15.6) | 12 (33.3) | 0.025* |
Enteral nutrition on diagnosis, n (%) | 125 (94.7) | 93 (96.9) | 32 (88.9) | 0.068 |
Outcome | ||||
ICU stay (days) (median, IQR25–75) | 14 (6–29) | 13.5 (6–28) | 14 (8–35) | 0.688 |
Hospital stay (median, IQR25–75) | 37.5 (18–61) | 39.5 (23–62.5) | 24.5 (15–54) | 0.091 |
Medication | ||||
Proton pump inhibitors, n (%) | 126 (95.5) | 91 (94.8) | 35 (97.2) | 0.550 |
Immunosuppressants, n (%) | 33 (25) | 18 (18.8) | 15 (41.7) | 0.007* |
Steroids > 10 mg/day, n (%) | 28 (21.2) | 14 (14.6) | 14 (38.9) | 0.002* |
Calcineurin inhibitors, n (%) | 12 (9.1) | 6 (6.3) | 6 (16.7) | 0.064 |
Mycophenolic acid, n (%) | 4 (3) | 2 (2.1) | 2 (5.6) | 0.300 |
Azathioprine (AZA), n (%) | 4 (3) | 2 (2.1) | 2 (5.6) | 0.300 |