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Table 2 Outcomes of patients with severe sepsis and septic shock according to the time to antibiotics

From: Implementation of earlier antibiotic administration in patients with severe sepsis and septic shock in Japan: a descriptive analysis of a prospective observational study

 Time to antibiotic use (min)p value
0–6061–120121–180181–240241–360361–1440
Crude in-hospital mortality among all patients, n/total (%), n = 112496/343 (28.0)66/327 (20.2)35/161 (21.7)19/94 (20.2)26/103 (25.2)21/96 (21.9)0.219
Crude in-hospital mortality among patients with septic shock, n/total (%), n = 70368/215 (31.6)47/207 (22.7)27/94 (28.7)16/61 (26.2)21/69 (30.4)16/57 (28.1)0.466
Crude in-hospital mortality among patients from ED, n/total (%), n = 63161/210 (29.1)36/194 (18.6)14/94 (14.9)8/45 (17.8)15/56 (26.8)4/32 (12.5)0.022
Adjusted in-hospital mortality among all patients (95% CI)a, n = 94928.7 (23.3–34.1)*21.6 (16.5–26.6)*23.2 (16.4–30.0)20.4 (12.1–28.7)20.5 (12.6–28.5)21.1 (12.5–29.7) 
Adjusted in-hospital mortality among patients with septic shock (95% CI)a, n = 61530.0 (23.5–36.5)22.3 (16.1–28.5)28.5 (19.3–37.6)27.4 (15.9–38.9)25.1 (15.2–35.1)21.6 (11.1–32.0) 
Adjusted in-hospital mortality among patients from ED (95% CI)a, n = 50327.9 (21.1–34.6)*18.4 (12.2–24.5)*17.8 (9.3–26.2)17.2 (5.4–28.9)24.1 (12.2–36.0)12.8 (5.7–25.0) 
Crude 28-day mortality, n/total (%), n = 111275/338 (22.2)55/325 (16.9)26/159 (16.4)15/92 (16.3)22/103 (21.4)17/95 (17.9)0.445
ICU-free days, median (IQR), n = 90220 (12–24)20 (13–24)20 (9–23)18 (6–24)18 (10–24)19 (1023)0.3522
Ventilator-free days21 (0–28)21 (8–28)22 (0–28)20 (0–27)21 (0–27)20 (0–28)0.3947
Length of hospital stay26 (13–46)22 (11–43)26 (13–49)21 (13–38)25 (12–54)29 (13–48)0.4827
  1. ED emergency department, CI confidence interval, ICU intensive care unit, IQR interquartile range
  2. *< 0.05
  3. aAdjusted by age, gender, admission source (emergency department, ward, or in intensive care unit), CCI, antibiotic use before arrival, site of infection (e.g., lung, abdomen, urinary tract, soft tissue, central nerve system, or blood stream-related), SOFA score, and intravenous fluid bolus completed within 3 h (30 mg/kg crystalloid)