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Table 2 Metabolic variables

From: Exogenous vasopressin dose-dependently modulates gastric microcirculatory oxygenation in dogs via V1A receptor

Parameter

Treatment

Baseline, 0.5 h

± VB, 1.0 h

Dose 1, 1.5 h

Dose 2, 2.0 h

Dose 3, 2.5 h

Dose 4, 3.0 h

PaO2 (mmHg)

C

149 ± 6

152 ± 10

155 ± 6

153 ± 9

158 ± 7

159 ± 6*

AVP

152 ± 7

156 ± 11

149 ± 4

154 ± 7

150 ± 5

153 ± 4

VB

152 ± 10

157 ± 13

155 ± 14

157 ± 10

159 ± 7

158 ± 6

AVP VB

149 ± 9

150 ± 7

162 ± 7*§

163 ± 14*#

158 ± 7

161 ± 9*

PaCO2 (mmHg)

C

36 ± 2

36 ± 2

36 ± 2

37 ± 2

36 ± 2

38 ± 2*

AVP

35 ± 1

36 ± 1

36 ± 1

37 ± 1*

37 ± 1*

37 ± 1

VB

36 ± 2

36 ± 1

36 ± 1

37 ± 2

37 ± 1

38 ± 2*

AVP VB

36 ± 1

37 ± 2

37 ± 2

36 ± 1

37 ± 1

37 ± 1

SaO2 (%)

C

98 ± 0.2

98 ± 0.3

99 ± 0.2

98 ± 0.3

99 ± 0.2

99 ± 0.2

AVP

99 ± 0.2

99 ± 0.3

98 ± 0.1

99 ± 0.2

98 ± 0.2

99 ± 0.1

VB

99 ± 0.3

99 ± 0.4

99 ± 0.4

99 ± 0.3

99 ± 0.2

99 ± 0.2

AVP VB

98 ± 0.3

98 ± 0.3

99 ± 0.2

99 ± 0.4

99 ± 0.2

99 ± 0.2

Hct (%)

C

37.9 ± 2.1

37.9 ± 2.0

37.8 ± 2.0

37.7 ± 2.1

37.5 ± 2.1

37.7 ± 2.1

AVP

37.7 ± 1.2

37.6 ± 1.1

37.6 ± 1.2

37.5 ± 1.2

37.3 ± 1.1

37.6 ± 1.1

VB

37.2 ± 1.9#

37.3 ± 2.0#

37.2 ± 2.1#

37.0 ± 2.0#

36.8 ± 1.9*#

36.6 ± 1.9*#

AVP VB

37.4 ± 1.7#

37.4 ± 1.7#

37.2 ± 1.8#§

37.0 ± 1.8*#§

36.9 ± 1.8*#§

36.9 ± 1.7*#§

Hb (g/dl)

C

12.3 ± 0.7

12.3 ± 0.7

12.3 ± 0.6

12.2 ± 0.7

12.2 ± 0.7*

12.3 ± 0.7

AVP

12.3 ± 0.4

12.2 ± 0.4

12.2 ± 0.4

12.2 ± 0.4

12.1 ± 0.4

12.2 ± 0.4

VB

12.1 ± 0.6#

12.1 ± 0.7#

12.1 ± 0.7#

12.0 ± 0.7#

12.0 ± 0.6#

11.9 ± 0.6*#

AVP VB

12.1 ± 0.6#

12.2 ± 0.5#

12.1 ± 0.6#§

12.0 ± 0.6#§

12.0 ± 0.7*#§

12.0 ± 0.6*#§

pH

C

7.38 ± 0.02

7.37 ± 0.02

7.36 ± 0.03*

7.36 ± 0.03*

7.36 ± 0.03*

7.35 ± 0.03*

AVP

7.39 ± 0.01#

7.39 ± 0.02#

7.38 ± 0.01#

7.37 ± 0.02*#

7.37 ± 0.01*

7.37 ± 0.01*#

VB

7.37 ± 0.01

7.37 ± 0.01

7.36 ± 0.01

7.35 ± 0.03*

7.36 ± 0.02*

7.35 ± 0.02*

AVP VB

7.39 ± 0.02

7.37 ± 0.02

7.37 ± 0.03*

7.36 ± 0.03*

7.35 ± 0.03*

7.36 ± 0.03*

HCO3− (mmol/l)

C

20.5 ± 0.5

20.2 ± 0.6

20.1 ± 0.9

20.1 ± 0.7

20.0 ± 0.3

20.5 ± 0.3

AVP

20.7 ± 0.6

21.0 ± 0.6#

20.8 ± 0.7#

20.8 ± 0.6#

20.8 ± 0.8#

20.5 ± 0.5

VB

20.4 ± 0.5

20.3 ± 0.4

20.2 ± 0.6

19.9 ± 1.0

20.0 ± 1.0

20.3 ± 1.1

AVP VB

21.0 ± 1.1

20.9 ± 1.1#

20.5 ± 1.2

20.2 ± 1.4*

20.0 ± 1.4*

20.2 ± 1.3*

Lactate (mmol/l)

C

1.5 ± 0.9

1.9 ± 1.2*

2.2 ± 1.4

2.1 ± 1.2

2.0 ± 1.0

1.9 ± 0.8

AVP

1.0 ± 0.5

1.2 ± 0.6#

1.3 ± 0.5#

1.3 ± 0.5#

1.3 ± 0.5#

1.3 ± 0.5

VB

0.9 ± 0.4

1.0 ± 0.3#

1.2 ± 0.5#

1.6 ± 1.1*

1.7 ± 1.1*

1.7 ± 0.9*

AVP VB

0.9 ± 0.4#

1.1 ± 0.4#

1.6 ± 0.7*

2.0 ± 1.2*

2.2 ± 1.3*§

2.1 ± 1.2*

  1. Metabolic variables of the different types of treatment—arterial oxygen partial pressure (PaO2), carbon dioxide partial pressure (PaCO2), arterial oxygen saturation (SaO2), hematocrit (Hct), hemoglobin concentration (Hb), pH, bicarbonate (HCO3−), and lactate plasma levels. Data are presented as mean ± SD for n = 6 dogs
  2. *p < 0.05 vs. baseline
  3. #p < 0.05 vs. control (C), 2-way ANOVA for repeated measurements followed by Dunnett’s post hoc test
  4. §p < 0.05 for AVP VB vs. AVP, 2-way ANOVA for repeated measurements followed by Bonferroni’s post hoc test
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Critical Care

ISSN: 1364-8535