Fig. 4

Hemodynamic variables. Cardiac output (CO, a), systemic oxygen delivery (DO₂, b), mean arterial pressure (MAP, c), and systemic vascular resistance (SVR, d) in anesthetized dogs in time control experiment (C), with sole V1A receptor blockade (VB) and with AVP dose escalation (dose 1, 0.001 ng/kg/min; dose 2, 0.01 ng/kg/min; dose 3, 0.1 ng/kg/min; dose 4, 1 ng/kg/min) with (AVP VB) or without (AVP) V1A receptor blockade. Data are presented as individual values + mean for n = 6 dogs; *p < 0.05 vs. baseline; ^#p < 0.05 vs. C, 2-way ANOVA for repeated measurements followed by Dunnett’s post hoc test; ^§p < 0.05 for AVP VB vs. AVP, 2-way ANOVA for repeated measurements followed by Bonferroni’s post hoc test