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Table 3 The association between cumulative fluid balance and mortality

From: The interactive effects of input and output on managing fluid balance in patients with acute kidney injury requiring continuous renal replacement therapy

 

7-day mortality

28-day mortality

HR (95% CI)

P

HR (95% CI)

P

24-h cumulative fluid balance* (per 1.0 L increase, n = 258)

 Unadjusted

1.15 (1.09–1.22)

< 0.001

1.14 (1.08–1.20)

< 0.001

 Adjusted model†

1.14 (1.06–1.22)

< 0.001

1.11 (1.04–1.18)

0.002

72-h cumulative fluid balance* (per 1.0 L increase, n = 191)

 Unadjusted

1.12 (1.07–1.16)

< 0.001

1.10 (1.06–1.14)

< 0.001

 Adjusted model†

1.10 (1.05–1.15)

< 0.001

1.07 (1.03–1.12)

0.001

  1. *Per 1.0 L increase
  2. †Adjusted for age, sex, body mass index, mean arterial pressure, Charlson Comorbidity Index, history of diabetes and hypertension, hemoglobin, baseline estimated glomerular filtration rate, Sequential Organ Failure Assessment score, use of vasopressor, and type of fluid administration. Mean arterial pressure, hemoglobin, Sequential Organ Failure Assessment score, use of vasopressor use, and type of fluid administration at each of baseline and 72-h after CRRT initiation were used for adjustment in 24-h and 72-h CFB models, respectively
  3. Abbreviation: HR hazard ratio, CI confidence interval