Table 5 Risk factors of delayed defervescence (time-to-defervescence ≥ 7 days) in 2469 febrile patients

Time-to-appropriate antibiotic (h)*

–

–

–

–

1.007 (1.005–1.009)

< 0.001

Nursing-home residents

55 (6.1)

57 (3.6)

1.71 (1.17–2.51)

0.005

NS

NS

Pitt bacteremia score ≥ 4 at ED arrival

271 (30.0)

151 (9.6)

4.01 (3.22–5.00)

< 0.001

3.35 (2.64–4.25)

< 0.001

Polymicrobial bacteremia

102 (11.3)

108 (6.9)

1.72 (1.29–2.28)

< 0.001

NS

NS

 Pneumonia

195 (21.6)

101 (6.5)

3.99 (3.09–5.15)

< 0.001

2.05 (1.53–2.73)

< 0.001

 Urinary tract

220 (24.3)

673 (43.0)

0.43 (0.36–0.51)

< 0.001

0.49 (0.40–0.60)

< 0.001

 Biliary tract

58 (6.4)

165 (10.5)

0.58 (0.43–0.79)

0.001

0.47 (0.33–0.66)

< 0.001

Fatal comorbidities (McCabe classification)

298 (33.0)

308 (19.7)

2.01 (1.67–2.42)

< 0.001

1.39 (1.09–1.76)

0.007

Comorbid malignancies

332 (36.7)

401 (25.6)

1.69 (1.41–2.01)

< 0.001

1.34 (1.07–1.68)

0.01