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Table 4 Twenty-eight-day mortality per pathogen minimum inhibitory concentration (MIC) in the 79 episodes of A. baumannii, P. aeruginosa, or K. pneumoniae isolated in respiratory samples obtained at baseline

From: Colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia (Magic Bullet study): an investigator-driven, open-label, randomized, noninferiority controlled trial

 

Colistin + levofloxacin group (n = 120), death/total number of cases (%)

Meropenem + levofloxacin group (n = 112), death/total number of cases (%)

p value

VAP caused by A. baumannii, P. aeruginosa, and K. pneumoniae (n = 79)

40 (48.8)

39 (52)

0.811

MIC distribution

 Meropenem MIC

  ≤ 2 mg/l—susceptible

4/16 (25)

5/18 (27.8)

0.885

  > 2–8 mg/l—intermediate

0/4 (0)

0/5 (0)

  > 8 mg/l—resistant

5/20 (25)

6/16 (37.5)

0.419

 Colistin MIC

  ≤ 2 mg/l—susceptible

9/35 (25.7)

8/32 (25)

0.947

  > 2 mg/l—resistant

0/5 (0)

3/7 (42.9)

0.091

  1. MIC minimum inhibitory concentration, VAP ventilator-associated pneumonia