Table 5 Secondary outcome parameters (length of stay, mortality, in-hospital complications, and morbidity rates)

 ICU stay (days)

1.2 (0.6–4.9)

1.7 (0.8–6.9)

< 0.01,  MW 0.46 (0.44–0.48)

0.02

 ICU stay survivors (days)

1.0 (0.6–3.9)

1.3 (0.7–5.2)

< 0.01,  MW 0.46 (0.44–0.49)

< 0.01

 ICU stay non-survivors (days)

4.9 (2.0–15.3)

7.2 (2.5–17.5)

0.11

> 0.20

 In-hospital stay (days)

14.0 (9.2–22.2)

14.8 (10.0–26.8)

0.01,  MW 0.47 (0.45–0.49)

> 0.20

 In-hospital stay survivors (days)

14.0 (9.2–24.0)

14.4 (10.1–26.2)

0.01,  MW 0.46 (0.44–0.49)

0.18

 In-hospital stay non-survivors (days)

14.2 (5.6–36.0)

16.0 (8.2–32.4)

> 0.20

> 0.20

 In-hospital 28-day mortality rate (n; %)

133; 8.8% (7.4–10.4%)

155; 10.3% (8.8–11.9%)

0.19

0.05

 In-hospital mortality rate (n; %)

198; 13.1% (11.5–15.0%)

213; 14.1% (12.4–16.0%)

> 0.20

0.15

 Myocardial infarction (n; %)

26; 1.7% (1.1–2.5%)

25; 1.7% (1.1–2.4%)

> 0.20

> 0.20

 Ischemic stroke (n; %)

35; 2.3% (1.6–3.2%)

21; 1.4% (0.9–2.1%)

0.08

0.06

 Pneumonia (n; %)

172; 11.4% (9.9–13.1%)

217; 14.4% (12.7–16.3%)

0.02, RR 0.79 (0.66–0.96)

< 0.01, OR 0.73 (0.58–0.91)

 Sepsis (n; %)

145; 9.6% (8.2–11.2%)

183; 12.2% (10.5–13.9%)

0.03, RR 0.79 (0.64–0.97)

0.01, OR 0.73 (0.57–0.94)

 Composite endpoint^c (n; %)

405; 26.9% (24.7–29.2%)

437; 29.0% (26.7–31.4%)

> 0.20

0.05, OR 0.84 (0.71–1.00)