In-line filtration of intravenous infusion may reduce organ dysfunction of adult critical patients

Table 4 Secondary outcome parameters (inflammation, cytokines)

	Fine filter cohort (n = 1506)	Control filter cohort (n = 1506)	P value^a	P value^b
Inflammation
Maximal interleukin-6 value (ng/l)	471.5 (258.8–1062.8)	540.5 (284.5–1147.5)	0.01, MW 0.47 (0.45–0.49)	0.01
Maximal interleukin-6 per interval (n; %)			–	–
0.0–50.0 ng/l	30; 2.0%	39; 2.6%
50.1–200.0 ng/l	188; 15.4%	188; 12.7%
200.1–500.00 ng/l	519; 35.0%	474; 32.0%
> 500.00 ng/l	726; 47.6%	778; 52.6%

This table shows the values of the secondary endpoint inflammation between the fine filter and control filter cohort. Interleukin-6 was significantly better for the fine filter cohort
Data are presented as the median (first quartile–third quartile), as the percentage rates (with 95% confidence intervals), or as the number (n) of patients, where indicated
^aP values were calculated using the Wilcoxon-Mann-Whitney U test for equality of mean. Mann-Whitney effect estimators (Delong method for AUC) are provided if the P value is significant
^bP values were calculated using the Wald test. The regression model includes baseline, cohort, age, sex, and surgery as regression variables. Odds ratios are provided if appropriate and if the P value is significant

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