From: In-line filtration of intravenous infusion may reduce organ dysfunction of adult critical patients
 | Fine filter cohort (n = 1506) | Control filter cohort (n = 1506) | P valuea | P valueb |
---|---|---|---|---|
Multi-organ dysfunction | ||||
 Maximal SOFA score | 9 (6–13) | 10 (6–13) | > 0.20 | 0.15 |
 Maximal SAPS II score | 53 (39–71) | 52 (34–72.25) | > 0.20 | < 0.01c |
 Maximal TISS-10 score | 23 (18–29.75) | 26 (18–30) | 0.08 | 0.06 |
 Maximal TISS-28 score | 44 (36.25–51) | 45 (36–51) | > 0.20 | 0.12 |
Lung dysfunction | ||||
 Minimal Horowitz index | 206 (119–290) | 191 (104.75–280) | 0.04, MW 0.52 (0.50–0.55) | 0.02 |
 ARDS score | 1 (1–2) | 2 (1–2) | 0.01, MW 0.47 (0.45–0.49) | < 0.01 |
  0, no ARDS (n; %) | 296; 22.6% | 215; 19.6% |  |  |
  1, mild ARDS (n; %) | 376; 28.8% | 302; 27.6% |  |  |
  2, moderate ARDS (n; %) | 377; 28.8% | 324; 29.6% |  |  |
  3, severe ARDS (n; %) | 258; 19.7% | 255; 23.3% |  |  |
Heart/lung dysfunction (ECMO) | ||||
 Patients on ECMO (n; %) | 30; 2.0% (1.3–2.8%) | 38; 2.5% (1.8–3.4%) | > 0.20 | > 0.20 |
 Cumulative duration (days) without first day | 4.5 (1.4–7.5) | 6.8 (4.8–12.4) | 0.01, MW 0.33 (0.19–0.46) | 0.09 |
 Cumulative duration (days) | 5.5 (2.4–8.5) | 8.2 (5.8–13.4) | 0.02, MW 0.33 (0.20–0.47) | 0.15 |
Acute kidney injury (AKI) | ||||
 Maximal creatinine value before dialysis (mg/dl) | 1.09 (0.84–1.74) | 1.12 (0.84–1.83) | 0.19 | < 0.01d |
 Maximal creatinine value before dialysis per interval (n; %) | 626; 41.9% | 600; 40.2% | – | – |
  0.00–1.00 mg/dl | 578; 38.7% | 574; 38.5% |  |  |
  1.01–2.00 mg/dl | 169; 11.3% | 167; 11.2% |  |  |
  2.01–3.00 mg/dl | 63; 4.2% | 79; 5.3% |  |  |
  3.01–4.00 mg/dl | 44; 2.9% | 51; 3.4% |  |  |
  4.01–6.00 mg/dl | 13; 0.9% | 20; 1.3% |  |  |
  > 6.00 mg/dl |  |  |  |  |
 Modified AKIN score rate (no AKI/mild AKI vs moderate AKI/severe AKI) | 11.8% (10.2–13.5%) | 13.7% (12.0–15.5%) | 0.11 | 0.06 |
 Modified AKIN score per classes | 1 (1–1) | 1 (1–1) | 0.11 | 0.05 |
  0, no AKI (n; %) | 1; 0.1% | 2; 0.1% |  |  |
  1, mild AKI (n; %) | 1316; 88.1% | 1284; 86.1% |  |  |
  2, moderate AKI (n; %) | 92; 6.2% | 101; 6.8% |  |  |
  3, severe AKI (n; %) | 84; 5.6% | 104; 7.0% |  |  |
 Dialysis rate (n; %) | 235; 15.6% (13.8–17.5%) | 247; 16.4% (14.6–18.4%) | > 0.20 | > 0.20 |
Brain dysfunction | ||||
 Maximal delirium score | 4 (1–7) | 3 (1–6) | > 0.20 | < 0.01e |