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Table 3 Secondary outcome parameters (multiple-organ dysfunction, lung dysfunction, acute kidney injury, brain dysfunction)

From: In-line filtration of intravenous infusion may reduce organ dysfunction of adult critical patients

 

Fine filter cohort (n = 1506)

Control filter cohort (n = 1506)

P valuea

P valueb

Multi-organ dysfunction

 Maximal SOFA score

9 (6–13)

10 (6–13)

> 0.20

0.15

 Maximal SAPS II score

53 (39–71)

52 (34–72.25)

> 0.20

< 0.01c

 Maximal TISS-10 score

23 (18–29.75)

26 (18–30)

0.08

0.06

 Maximal TISS-28 score

44 (36.25–51)

45 (36–51)

> 0.20

0.12

Lung dysfunction

 Minimal Horowitz index

206 (119–290)

191 (104.75–280)

0.04, MW 0.52 (0.50–0.55)

0.02

 ARDS score

1 (1–2)

2 (1–2)

0.01, MW 0.47 (0.45–0.49)

< 0.01

  0, no ARDS (n; %)

296; 22.6%

215; 19.6%

  

  1, mild ARDS (n; %)

376; 28.8%

302; 27.6%

  

  2, moderate ARDS (n; %)

377; 28.8%

324; 29.6%

  

  3, severe ARDS (n; %)

258; 19.7%

255; 23.3%

  

Heart/lung dysfunction (ECMO)

 Patients on ECMO (n; %)

30; 2.0% (1.3–2.8%)

38; 2.5% (1.8–3.4%)

> 0.20

> 0.20

 Cumulative duration (days) without first day

4.5 (1.4–7.5)

6.8 (4.8–12.4)

0.01, MW 0.33 (0.19–0.46)

0.09

 Cumulative duration (days)

5.5 (2.4–8.5)

8.2 (5.8–13.4)

0.02, MW 0.33 (0.20–0.47)

0.15

Acute kidney injury (AKI)

 Maximal creatinine value before dialysis (mg/dl)

1.09 (0.84–1.74)

1.12 (0.84–1.83)

0.19

< 0.01d

 Maximal creatinine value before dialysis per interval (n; %)

626; 41.9%

600; 40.2%

–

–

  0.00–1.00 mg/dl

578; 38.7%

574; 38.5%

  

  1.01–2.00 mg/dl

169; 11.3%

167; 11.2%

  

  2.01–3.00 mg/dl

63; 4.2%

79; 5.3%

  

  3.01–4.00 mg/dl

44; 2.9%

51; 3.4%

  

  4.01–6.00 mg/dl

13; 0.9%

20; 1.3%

  

  > 6.00 mg/dl

    

 Modified AKIN score rate (no AKI/mild AKI vs moderate AKI/severe AKI)

11.8% (10.2–13.5%)

13.7% (12.0–15.5%)

0.11

0.06

 Modified AKIN score per classes

1 (1–1)

1 (1–1)

0.11

0.05

  0, no AKI (n; %)

1; 0.1%

2; 0.1%

  

  1, mild AKI (n; %)

1316; 88.1%

1284; 86.1%

  

  2, moderate AKI (n; %)

92; 6.2%

101; 6.8%

  

  3, severe AKI (n; %)

84; 5.6%

104; 7.0%

  

 Dialysis rate (n; %)

235; 15.6% (13.8–17.5%)

247; 16.4% (14.6–18.4%)

> 0.20

> 0.20

Brain dysfunction

 Maximal delirium score

4 (1–7)

3 (1–6)

> 0.20

< 0.01e

  1. This table shows the values of the secondary endpoints multi-organ, heart, lung, and brain dysfunction between the fine filter and control filter cohort. Lung (Horowitz value and ARDS score) dysfunction was significantly better for the fine filter cohort
  2. Data are presented as the median (first quartile–third quartile), as the percentage rates (with 95% confidence intervals), or as the number (n) of patients, where indicated
  3. aP values were calculated using the Wilcoxon-Mann-Whitney U test for equality of means, Pearson’s chi-square test, or Fisher’s exact test, as appropriate. Mann-Whitney effect estimators (Delong method for AUC) and risk ratios are provided as appropriate and if the P value is significant
  4. bP values were calculated using the Wald test. The regression model includes baseline, cohort, age, sex, and surgery as regression variables. Odds ratios are provided if appropriate and if the P value is significant
  5. cMaximal SAPS II score was better for the fine filter cohort
  6. dMaximal creatinine value was better for the fine filter cohort
  7. eMaximal delirium score was better for the fine filter cohort