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Table 4 NEWS and MR-proADM values upon ED presentation and 72 h within patient subgroups

From: Biomarkers and clinical scores to identify patient populations at risk of delayed antibiotic administration or intensive care admission

Patient subgroups Patient populations stratified by NEWS and MR-proADM
MR-proADM (nmol/L) NEWS (points) MR-proADM (nmol/L) NEWS (points) MR-proADM (nmol/L) NEWS (points) MR-proADM (nmol/L) NEWS (points)
< 1.77 < 5 ≥ 1.77 < 5 < 1.77 ≥ 5 ≥ 1.77 ≥ 5
Population, N (%) 425 (62.1%) 74 (10.8%) 100 (14.6%) 85 (12.8%)
Infection related 28-day mortality, N (%) 0 (0.0%) 10 (13.5%) 6 (6.0%) 14 (16.5%)
NEWS: surviving patients
 ED admission (points) 1.72 (1.29) 2.18 (1.39) 7.18 (1.71) 7.97 (2.62)
 72 h (points) 1.54 (1.62) 2.08 (2.26) 4.57 (3.22) 3.61 (2.48)
p value 0.182 0.784 < 0.001 < 0.001
NEWS: non-surviving patients
 ED admission (points) NA 2.60 (0.97) 6.20 (1.10) 8.36 (2.69)
 72 h (points) NA 2.63 (2.07) 4.20 (2.03) 4.90 (3.31)
p value NA 0.875 < 0.05 < 0.05
MR-proADM: surviving patients
 ED admission (nmol/L) 0.88 (0.36) 2.78 (1.16) 1.23 (0.34) 3.39 (1.47)
 72 h (nmol/L) 0.91 (0.58) 1.80 (1.11) 1.08 (0.50) 2.13 (1.36)
p value 0.56 < 0.001 < 0.01 < 0.001
MR-proADM: non-surviving patients
 ED admission (nmol/L) NA 3.22 (1.37) 1.30 (0.29) 2.77 (1.38)
 72 h (nmol/L) NA 3.95 (1.02) 1.41 (0.35) 3.69 (2.49)
p value NA 0.085 0.548 0.148
  1. All NEWS and MR-proADM values are expressed as mean (standard deviation). MR-proADM mid-regional proadrenomedullin, N number, NEWS National Early Warning Score