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Table 2 Multivariate Cox regression analysis for the prediction of 28-day mortality upon ED presentation and after 72 h of hospitalisation

From: Biomarkers and clinical scores to identify patient populations at risk of delayed antibiotic administration or intensive care admission

Biomarker or clinical score Patients (N) Number of events (N) LR χ2 p value HR [95% CI]
28-day mortality prediction upon ED presentation
 MR-proADM 684 30 53.1 < 0.001 3.8 [2.2 – 6.5]
 PCT 684 30 38.2 < 0.001 1.7 [1.1 – 2.5]
 Lactate 533 30 34.8 < 0.001 1.5 [1.1 – 2.1]
 CRP 646 28 29.0 < 0.001 0.9 [0.6 – 1.4]
 SOFA 684 30 53.7 < 0.001 3.2 [2.1 – 5.0]
 qSOFA 684 30 46.5 < 0.001 2.3 [1.6 – 3.5]
 NEWS 684 30 42.2 < 0.001 2.0 [1.3 – 2.9]
 CRB-65 684 30 39.8 < 0.001 1.5 [1.1 – 2.0]
 SIRS 684 30 35.4 < 0.001 1.4 [1.0 – 1.9]
28-day mortality prediction after 72 h of hospitalisation
 MR-proADM 375 25 36.6 < 0.001 3.0 [1.8 – 4.9]
 PCT 370 25 26.2 < 0.001 1.6 [1.1 – 2.4]
 Lactate 266 24 20.1 < 0.01 1.0 [0.7 – 1.5]
 CRP 281 20 17.6 < 0.001 0.8 [0.4 – 1.3]
 SOFA 375 25 33.7 < 0.001 2.0 [1.4 – 2.7]
 qSOFA 376 25 22.5 < 0.001 1.4 [0.8 – 2.3]
 NEWS 376 25 26.5 < 0.001 1.6 [1.1 – 2.3]
 CRB-65 376 25 22.3 < 0.001 1.3 [0.8 – 2.2]
 SIRS 376 25 24.9 < 0.001 1.5 [1.0 – 2.3]
  1. Multivariate analysis was adjusted by age, diabetes, malignancy, and liver and renal disease variables. CI confidence interval, CRB-65 severity score for community-acquired pneumonia, CRP C-reactive protein, DF degrees of freedom, LR likelihood ratio, MR-proADM mid-regional proadrenomedullin, N number, NEWS National Early Warning Score, HR hazard ratio, PCT procalcitonin, qSOFA quick Sequential Organ Failure Assessment, SIRS systemic inflammatory response syndrome, SOFA Sequential Organ Failure Assessment