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Table 2 Multivariate Cox regression analysis for the prediction of 28-day mortality upon ED presentation and after 72 h of hospitalisation

From: Biomarkers and clinical scores to identify patient populations at risk of delayed antibiotic administration or intensive care admission

Biomarker or clinical score

Patients (N)

Number of events (N)

LR χ2

p value

HR [95% CI]

28-day mortality prediction upon ED presentation

 MR-proADM

684

30

53.1

< 0.001

3.8 [2.2 – 6.5]

 PCT

684

30

38.2

< 0.001

1.7 [1.1 – 2.5]

 Lactate

533

30

34.8

< 0.001

1.5 [1.1 – 2.1]

 CRP

646

28

29.0

< 0.001

0.9 [0.6 – 1.4]

 SOFA

684

30

53.7

< 0.001

3.2 [2.1 – 5.0]

 qSOFA

684

30

46.5

< 0.001

2.3 [1.6 – 3.5]

 NEWS

684

30

42.2

< 0.001

2.0 [1.3 – 2.9]

 CRB-65

684

30

39.8

< 0.001

1.5 [1.1 – 2.0]

 SIRS

684

30

35.4

< 0.001

1.4 [1.0 – 1.9]

28-day mortality prediction after 72 h of hospitalisation

 MR-proADM

375

25

36.6

< 0.001

3.0 [1.8 – 4.9]

 PCT

370

25

26.2

< 0.001

1.6 [1.1 – 2.4]

 Lactate

266

24

20.1

< 0.01

1.0 [0.7 – 1.5]

 CRP

281

20

17.6

< 0.001

0.8 [0.4 – 1.3]

 SOFA

375

25

33.7

< 0.001

2.0 [1.4 – 2.7]

 qSOFA

376

25

22.5

< 0.001

1.4 [0.8 – 2.3]

 NEWS

376

25

26.5

< 0.001

1.6 [1.1 – 2.3]

 CRB-65

376

25

22.3

< 0.001

1.3 [0.8 – 2.2]

 SIRS

376

25

24.9

< 0.001

1.5 [1.0 – 2.3]

  1. Multivariate analysis was adjusted by age, diabetes, malignancy, and liver and renal disease variables. CI confidence interval, CRB-65 severity score for community-acquired pneumonia, CRP C-reactive protein, DF degrees of freedom, LR likelihood ratio, MR-proADM mid-regional proadrenomedullin, N number, NEWS National Early Warning Score, HR hazard ratio, PCT procalcitonin, qSOFA quick Sequential Organ Failure Assessment, SIRS systemic inflammatory response syndrome, SOFA Sequential Organ Failure Assessment