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Table 2 Respiratory mechanics at different PEEP in patients with and without intrinsic PEEP

From: Dynamic hyperinflation and intrinsic positive end-expiratory pressure in ARDS patients

Parameter

Patients with intrinsic PEEP (n = 87)

Patients without intrinsic PEEP (n = 130)

PPEEPi

PPEEP

PPEEPix PEEP

Tidal volume (mL)

0.012

0.357

0.874

 5 cmH2O

480 [430–540]

520 [445–600]

   

 15 cmH2O

480 [430–540]

510 [430–590]

   

Respiratory rate (breath/min)

< 0.001

0.992

0.954

 5 cmH2O

18 [15–20]

15 [13–19]

   

 15 cmH2O

18 [15–20]

15 [13–19]

   

Minute ventilation (L/min)

0.007

0.559

0.048^

 5 cmH2O

8.6 [7.6–10.2]

8.0 [6.9–9.4]

   

 15 cmH2O

8.6 [7.3–10.7]

7.9 [6.8–9.4]

   

Plateau pressure (cmH2O)

0.726

< 0.001

0.061

 5 cmH2O

18.4 [16.3–21.4]

18.0 [15.5–20.2]

   

 15 cmH2O

27.8 [24.9–30.0]

28.0 [25.4–30.0]

   

Expiratory time (s)

0.002

0.884

0.774

 5 cmH2O

2.36 [1.99–2.93]

2.80 [2.12–3.43]

   

 15 cmH2O

2.31 [1.92–2.92]

2.80 [2.12–3.40]

   

Total resistance (cmH2O s L−1)

0.246

0.679

0.286

 5 cmH2O

13 [11–20]

14 [11–18]

   

 15 cmH2O

13 [10–18]

15 [12–19]

   

Respiratory system compliance (mL cmH2O−1)

0.170

0.023

0.698

 5 cmH2O

43 [34–53]

41 [31–52]

   

 15 cmH2O

41 [30–51]

38 [33–49]

   

Lung compliance (mL cmH2O−1)

0.004

0.088

0.250

 5 cmH2O

57 [44–78]

57 [43–71]

   

 15 cmH2O

57 [44–72]

54 [41–66]

   

Chest wall compliance (mL cmH2O−1)

0.981

0.564

0.388

 5 cmH2O

174 [125–272]

178 [116–269]

   

 15 cmH2O

160 [103–272]

158 [111–238]

   

Time constant (s)

0.192

0.549

0.554

 5 cmH2O

0.65 [0.43–0.79]

0.63 [0.45–1.00]

   

 15 cmH2O

0.56 [0.36–0.77]

0.57 [0.44–0.73]

   
  1. Data are expressed as median [I.Q. range] as appropriate
  2. Two-way repeated measures analysis of variance (ANOVA) followed by all pairwise multiple comparison procedures (Holm-Sidak method) were used for analysis
  3. n sample size, PEEP positive-end expiratory pressure
  4. ^p < 0.05: minute ventilation is higher in patients with intrinsic PEEP than those without intrinsic PEEP at PEEP 15. There are no other significant interactions
  5. Italics: for all the statistical data
  6. Bold italics: for statistical significant data