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Table 2 Respiratory mechanics at different PEEP in patients with and without intrinsic PEEP

From: Dynamic hyperinflation and intrinsic positive end-expiratory pressure in ARDS patients

ParameterPatients with intrinsic PEEP (n = 87)Patients without intrinsic PEEP (n = 130)PPEEPiPPEEPPPEEPix PEEP
Tidal volume (mL)0.0120.3570.874
 5 cmH2O480 [430–540]520 [445–600]   
 15 cmH2O480 [430–540]510 [430–590]   
Respiratory rate (breath/min)< 0.0010.9920.954
 5 cmH2O18 [15–20]15 [13–19]   
 15 cmH2O18 [15–20]15 [13–19]   
Minute ventilation (L/min)0.0070.5590.048^
 5 cmH2O8.6 [7.6–10.2]8.0 [6.9–9.4]   
 15 cmH2O8.6 [7.3–10.7]7.9 [6.8–9.4]   
Plateau pressure (cmH2O)0.726< 0.0010.061
 5 cmH2O18.4 [16.3–21.4]18.0 [15.5–20.2]   
 15 cmH2O27.8 [24.9–30.0]28.0 [25.4–30.0]   
Expiratory time (s)0.0020.8840.774
 5 cmH2O2.36 [1.99–2.93]2.80 [2.12–3.43]   
 15 cmH2O2.31 [1.92–2.92]2.80 [2.12–3.40]   
Total resistance (cmH2O s L−1)0.2460.6790.286
 5 cmH2O13 [11–20]14 [11–18]   
 15 cmH2O13 [10–18]15 [12–19]   
Respiratory system compliance (mL cmH2O−1)0.1700.0230.698
 5 cmH2O43 [34–53]41 [31–52]   
 15 cmH2O41 [30–51]38 [33–49]   
Lung compliance (mL cmH2O−1)0.0040.0880.250
 5 cmH2O57 [44–78]57 [43–71]   
 15 cmH2O57 [44–72]54 [41–66]   
Chest wall compliance (mL cmH2O−1)0.9810.5640.388
 5 cmH2O174 [125–272]178 [116–269]   
 15 cmH2O160 [103–272]158 [111–238]   
Time constant (s)0.1920.5490.554
 5 cmH2O0.65 [0.43–0.79]0.63 [0.45–1.00]   
 15 cmH2O0.56 [0.36–0.77]0.57 [0.44–0.73]   
  1. Data are expressed as median [I.Q. range] as appropriate
  2. Two-way repeated measures analysis of variance (ANOVA) followed by all pairwise multiple comparison procedures (Holm-Sidak method) were used for analysis
  3. n sample size, PEEP positive-end expiratory pressure
  4. ^p < 0.05: minute ventilation is higher in patients with intrinsic PEEP than those without intrinsic PEEP at PEEP 15. There are no other significant interactions
  5. Italics: for all the statistical data
  6. Bold italics: for statistical significant data