Adaptive mechanical ventilation with automated minimization of mechanical power—a pilot randomized cross-over study

Table 3 Results for subgroup of patients with acute respiratory distress syndrome (ARDS)

Parameter	AVM	AVM2	p value
V_T (ml/kg)	7.9 ± 0.5	6.6 ± 0.8	< 0.0001
ΔP_stat (cmH₂O)	13.3 ± 2.7	11.8 ± 1.7	0.0044
P_insp (cmH₂O)	23.0 ± 2.6	20.5 ± 2.0	< 0.0001
RR (1/min)	13.0 ± 2.0	16.3 ± 2.9	0.0001
Mechanical Power (J/min)	17.5 ± 4.6	15.6 ± 3.2	0.006
V̇ _A	4.1 ± 0.7	3.9 ± 0.9	0.26
P_{aw, mean} (cmH₂O)	13.7 ± 0.9	14.3 ± 1.1	0.11
C_rs (ml/cmH₂O)	47.3 ± 9.1	43.8 ± 11.9	0.12
R_insp (cmH₂O/l/s)	10.8 ± 2.7	9.5 ± 1.6	0.02
RC_e (s)	0.73 ± 0.18	0.71 ± 0.23	0.53
PaO₂/FiO₂ (mmHg)	218 ± 61	195 ± 55	0.01
PaCO₂ (mmHg)	38.5 ± 4.0	40.2 ± 6.1	0.19
pH	7.44 ± 0.08	7.43 ± 0.08	0.18
MAP (mmHg)	82 ± 12	81 ± 12	0.75
HR (1/min)	63 ± 11	64 ± 11	0.42

Parametric data are presented as mean ± standard deviation; nonparametric data are presented as median (interquartile range). p values were calculated using a two-sided paired t test or a Wilcoxon matched-pairs test for parametric and nonparametric data, respectively. V_T tidal volume, ΔP_stat driving pressure (measured during end-inspiratory occlusion maneuver), P_insp inspiratory airway pressure (measured during ongoing ventilation), RR respiratory rate, V̇_A alveolar minute ventilation, P_aw,mean mean airway pressure, C_rs static respiratory system compliance, R_insp inspiratory resistance, RC_e expiratory time constant, PaO₂/FiO₂ ratio of arterial partial pressure of oxygen to inspired fraction of oxygen, PaCO₂ arterial partial pressure of carbon dioxide, MAP mean arterial pressure, HR heart rate

ISSN: 1364-8535