Table 1 Clinical and biological data of 208 patients before the second spontaneous breathing trial (SBT)
From: Myocardial ischemia during ventilator weaning: a prospective multicenter cohort study
Clinical and biological data | All patients (n = 208) | Weaning outcome | p | ||
|---|---|---|---|---|---|
Short (n = 51) | Difficult (n = 95) | Prolonged (n = 62) | |||
Clinical data | |||||
Body weight, kg | 78 (66–95) | 81 (68–90) | 78 (66–96) | 78 (65–92) | 0.962 |
Variation of weight since admission, kg | 0 (−2 to 4) | 0 (−2 to 4) | 0 (−1 to 3) | 1 (−2 to 5) | 0.965 |
SOFA score | 3 (3–5) | 3 (2–4) | 3 (3–5) | 4 (3–6) | 0.130 |
Richmond Agitation-Sedation Score | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0.230 |
Temperature, °C | 37.8 (37.5–38.2) | 37.8 (37.5–38.2) | 37.7 (37.3–38.2) | 37.7 (37.4–38.1) | 0.745 |
Fluid balance since admission, ml | 4500 (1677–10,966) | 3471 (737–6498) | 4161 (1052–9654) | 8653 (2838–15,121) | 0.002 |
Use of diuretics since admission | 111 (53.4) | 26 (51.0) | 48 (50.5) | 37 (59.7) | 0.492 |
Spontaneous cough | 155 (76.0) | 43 (86.0) | 69 (73.4) | 43 (71.7) | 0.130 |
Delirium (CAM-ICU) | 70 (33.6) | 16 (31.4) | 32 (33.7) | 22 (35.5) | 0.915 |
New or persistent radiological pulmonary consolidation | 58 (28.3) | 14 (28.6) | 20 (21.1) | 24 (39.3) | 0.047 |
Duration of mechanical ventilation since intubation | 6 (4–13) | 6 (3–8) | 6 (3–9) | 13 (7–20) | < 0.001 |
Mechanical ventilation | 0.013 | ||||
Assist-control ventilation | 35 (16.9) | 5 (9.8) | 13 (13.8) | 17 (27.4) | |
Pressure support ventilation | 170 (82.1) | 46 (90.2) | 81 (86.2) | 43 (69.4) | |
Others | 2 (1.0) | 0 (0.0) | 0 (0.0) | 2 (3.2) | |
Heat and moisture exchanger | 141 (68.4) | 31 (60.8) | 65 (69.9) | 45 (72.6) | 0.374 |
Pressure support level, cmH2O | 12 (10–14) | 12 (10–13) | 12 (10–14) | 12 (10–14) | 0.229 |
PEEP, cmH2O | 5 (5–6) | 5 (5–5) | 5 (5–6) | 5 (5–5) | 0.362 |
Tidal volume, ml | 438 (376–499) | 434 (359–479) | 443 (380–512) | 430 (378–472) | 0.553 |
Tidal volume per kilogram body weight, mL/kg | 7.1 (6.2–8.1) | 7.0 (6.3–8.3) | 7.3 (6.3–8.2) | 6.7 (6.1–7.9) | 0.453 |
Respiratory rate, breaths per minute | 26 (20–31) | 27 (19–32) | 25 (21–29) | 26 (20–31) | 0.804 |
Number of tracheal suctions during 24 h | 7 (5–11) | 8 (6–10) | 8 (5–12) | 6 (4–11) | 0.424 |
MRC muscle scale | 50 (9–60) | 60 (40–60) | 52 (20–60) | 25 (5–48) | 0.002 |
Biological data | |||||
White blood count, G/l | 11.4 (8.3–15.2) | 11.1 (7.9–13.4) | 11.8 (8.9–15.1) | 12.4 (7.8–16.9) | 0.460 |
Creatinine, micromol/l | 78 (53–140) | 82 (58–121) | 77 (52–142) | 75 (52–147) | 0.761 |
Protid, g/l | 59 (54–65) | 59 (55–66) | 57 (53–64) | 61 (55–66) | 0.224 |
Hemoglobin, g/dl | 9.4 (8.2–10.8) | 9.6 (8.3–11.2) | 9.6 (8.4–10.8) | 9.0 (7.9–10.1) | 0.042 |
Positive lower respiratory tract sample | 30 | 9 | 10 | 11 | 0.341 |
Time since intubation, days | 6 (4–13) | 6 (3–8) | 6 (3–9) | 13 (7–20) | < 0.001 |
Type of the second SBT | 0.455 | ||||
T-piece | 204 (98.1) | 51 (100.0) | 93 (97.9) | 60 (96.8) | |
Pressure support ventilation without PEEP | 4 (2.0) | 0 (0.0) | 2 (2.1) | 2 (3.2) | |
Duration of the second SBT, minutes | 60 (17–120) | 120 (55–123) | 50 (18–120) | 24 (10–97) | < 0.001 |
Failure of the second SBT | 132 (63.5) | 16 (31.4) | 68 (71.6) | 48 (77.4) | < 0.001 |
Reasons for second SBT failurea | |||||
Respiratory rate > 35/min | 89 (65.4) | 10 (58.8) | 43 (61.4) | 36 (73.5) | 0.329 |
SpO2 < 90% | 47 (34.6) | 6 (35.3) | 25 (35.7) | 16 (32.7) | 0.940 |
PCO2 > 50 mmHg | 9 (6.6) | 0 (0.0) | 8 (11.4) | 1 (2.0) | 0.064 |
Heart rate > 140/min | 4 (2.9) | 0 (0.0) | 2 (2.9) | 2 (4.1) | 0.691 |
Systolic arterial pressure > 180 mmHg | 21 (15.4) | 2 (11.8) | 10 (14.3) | 9 (18.4) | 0.752 |
Increased work of breathing or distress | 68 (50.0) | 8 (47.1) | 33 (47.1) | 27 (55.1) | 0.671 |
Alteration of consciousness | 6 (4.4) | 0 (0.0) | 1 (1.4) | 5 (10.2) | 0.046 |