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Table 2 Results of the multivariable mixed regression model with center effect on subsequent risk for endotracheal intubation

From: Center effect in intubation risk in critically ill immunocompromised patients with acute hypoxemic respiratory failure

 

Trial-OH cohort

High randomized controlled trial

No. of intubation/no. of observation

398/703

320/776

Center effect*

 Estimated true inter-hospital variance**

0.156

0.186

 Median odds ratio***

1.48 [1.30–1.72]

1.51 [1.36–1.68]

 Predicted probability of intubation, mean (min-max) across centers

0.56 (0.46–0.70)

0.41 (0.28–0.55)

p value for center effect

0.013

0.004

  1. *Results were adjusted on age, Charlson comorbidity index, type of immunosuppression, allogeneic stem cell transplantation, sex, performance status > 2, diagnosis of acute respiratory failure, Pa02/FiO2 ratio in four categories (> 300, 200–300, 100–200, ≤100 mmHg, with > 300 mmHg as reference), respiratory rate > 30/min, SOFA score without respiratory item
  2. **Intercept variance
  3. ***The median odds ratio (MOR) is defined as the median value of the odds ratio between the hospital at highest risk and the hospital at lowest risk for two randomly chosen hospitals