Demographic and clinical data | Trial-OH cohort (n = 703) | High randomized controlled trial (n = 776) |
---|---|---|
Characteristics of the patients | ||
Demographics | ||
Age, median [IQR], years | 61 [51.0–71.0] | 64.0 [56.0–71.0] |
Male sex, n (%) | 429 (61.0) | 517 (66.2) |
BMI, kg/m2 | 24.6 [21.6–27.7] | 24.9 [22.3–28.1] |
Source of admission | ||
ER or ambulance | 298 (42.4) | 327 (42) |
Night or weekend admissions | 434 (61.7) | |
Comorbidities | ||
Respiratory | 199 (28.3) | 242 (31.2) |
Heart failure | 98 (14) | 50 (6.4) |
Kidney disease | 64 (9) | 97 (12.5) |
Charlson score | 4 [3.0–6.0] | 5.0 [3.0–7.0] |
Underlying conditions | ||
Hematologic malignancies | 665 (94.6) | 348 (45) |
Solid tumors | 38 (5.4) | 265 (34) |
Immunosuppressive drugs | – | 268 (35) |
Remission of malignancy | 293 (41.7) | 141 (18.2) |
Autologous stem cell transplantation | 104 (14.8) | 48 (6.2) |
Allogeneic stem cell transplantation | 113 (16.1) | 61 (7.9) |
Poor performance status (> 2) | 149 (21.2) | 282 (36.3) |
Clinical parameters at baseline | ||
Respiratory rate, breaths/min | 32 [26.0–38.0] | 28.0 [23.0–33.0] |
Oxygen flow, l/min | 6 [3.0–10.0] | 11.0 [6.0–15.0] |
Glasgow coma score | 15 [15.0–15.0] | 15.0 [15.0–15.0] |
Neutropenia | 203 (28.9) | 136 (17.5) |
Number of quadrants on chest X-ray | 2.0 [1.0–4.0] | 2.0 [2.0–4.0] |
Arterial blood gas at baseline | ||
pH, units | 7.40 [7.31–7.46] | 7.43 [7.39–7.47] |
PaCO2, mmHg | 37.0 [31.0–44.0] | 35.0 [30.5–39.0] |
PaO2/FiO2 ratio, mmHg | 161.4 [113.0–226.4] | 132.0 [93.0–176.0] |
Severity of PaO2/FiO2 ratio at baseline | ||
PaO2/FiO2 > 300 mmHg | 100 (14.2) | 38 (4.9) |
PaO2/FiO2 200–300 mmHg | 125 (17.8) | 104 (13.4) |
PaO2/FiO2 100–200 mmHg | 340 (48.4) | 351 (45.2) |
PaO2/FiO2 ≤ 100 mmHg | 138 (19.6) | 231 (29.8) |
Organ dysfunction at day 1 | ||
SOFA score without respiratory item | 5.00 [3.0–8.0] | 3.00 [3.0–4.0] |
Use of vasopressor | 225 (32.0) | 117 (15) |
ARF etiology | ||
Bacterial infection | 269 (38.2) | 355 (45.7) |
Opportunist germs infection | 89 (12.6) | 93 (12.0) |
Disease-related infiltrates/drug-related toxicity | 73 (10.4) | 92 (11.9) |
Cardiogenic pulmonary edema | 58 (8.2) | 8 (1.0) |
Undetermined | 100 (14.2) | 176 (22.7) |
Others | 104 (14.8) | 103 (13.3) |
NA | 10 (1.4) | 2 (0.3) |
Outcome | ||
Invasive mechanical ventilation | 398 (57) | 320 (41.5) |
ICU mortality | 228 (32.4) | 245 (31.6) |
Hospital mortality | 309 (44.0) | 322 (41.5) |
ICU length of stay | 6.0 [3.0–12.0] | 7.0 [4.0–13.5] |
Hospital length of stay, days | 15.0 [7.0–29.0] | 26.0 [15.0–42.0] |