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Table 1 Characteristics of patients at ICU admission

From: Center effect in intubation risk in critically ill immunocompromised patients with acute hypoxemic respiratory failure

Demographic and clinical data

Trial-OH cohort (n = 703)

High randomized controlled trial (n = 776)

Characteristics of the patients

 Demographics

  Age, median [IQR], years

61 [51.0–71.0]

64.0 [56.0–71.0]

  Male sex, n (%)

429 (61.0)

517 (66.2)

  BMI, kg/m2

24.6 [21.6–27.7]

24.9 [22.3–28.1]

 Source of admission

  ER or ambulance

298 (42.4)

327 (42)

  Night or weekend admissions

434 (61.7)

 

 Comorbidities

  Respiratory

199 (28.3)

242 (31.2)

  Heart failure

98 (14)

50 (6.4)

  Kidney disease

64 (9)

97 (12.5)

  Charlson score

4 [3.0–6.0]

5.0 [3.0–7.0]

 Underlying conditions

  Hematologic malignancies

665 (94.6)

348 (45)

  Solid tumors

38 (5.4)

265 (34)

  Immunosuppressive drugs

268 (35)

  Remission of malignancy

293 (41.7)

141 (18.2)

  Autologous stem cell transplantation

104 (14.8)

48 (6.2)

  Allogeneic stem cell transplantation

113 (16.1)

61 (7.9)

  Poor performance status (> 2)

149 (21.2)

282 (36.3)

 Clinical parameters at baseline

  Respiratory rate, breaths/min

32 [26.0–38.0]

28.0 [23.0–33.0]

  Oxygen flow, l/min

6 [3.0–10.0]

11.0 [6.0–15.0]

  Glasgow coma score

15 [15.0–15.0]

15.0 [15.0–15.0]

  Neutropenia

203 (28.9)

136 (17.5)

  Number of quadrants on chest X-ray

2.0 [1.0–4.0]

2.0 [2.0–4.0]

 Arterial blood gas at baseline

  pH, units

7.40 [7.31–7.46]

7.43 [7.39–7.47]

  PaCO2, mmHg

37.0 [31.0–44.0]

35.0 [30.5–39.0]

  PaO2/FiO2 ratio, mmHg

161.4 [113.0–226.4]

132.0 [93.0–176.0]

 Severity of PaO2/FiO2 ratio at baseline

  PaO2/FiO2 > 300 mmHg

100 (14.2)

38 (4.9)

  PaO2/FiO2 200–300 mmHg

125 (17.8)

104 (13.4)

  PaO2/FiO2 100–200 mmHg

340 (48.4)

351 (45.2)

  PaO2/FiO2 ≤ 100 mmHg

138 (19.6)

231 (29.8)

 Organ dysfunction at day 1

  SOFA score without respiratory item

5.00 [3.0–8.0]

3.00 [3.0–4.0]

  Use of vasopressor

225 (32.0)

117 (15)

 ARF etiology

  Bacterial infection

269 (38.2)

355 (45.7)

  Opportunist germs infection

89 (12.6)

93 (12.0)

  Disease-related infiltrates/drug-related toxicity

73 (10.4)

92 (11.9)

  Cardiogenic pulmonary edema

58 (8.2)

8 (1.0)

  Undetermined

100 (14.2)

176 (22.7)

  Others

104 (14.8)

103 (13.3)

  NA

10 (1.4)

2 (0.3)

 Outcome

  Invasive mechanical ventilation

398 (57)

320 (41.5)

  ICU mortality

228 (32.4)

245 (31.6)

  Hospital mortality

309 (44.0)

322 (41.5)

  ICU length of stay

6.0 [3.0–12.0]

7.0 [4.0–13.5]

  Hospital length of stay, days

15.0 [7.0–29.0]

26.0 [15.0–42.0]

  1. Values are given in N (%) or median [IQR]
  2. Abbreviations: IQR interquartile range, ICU intensive care unit, SOFA Sequential Organ Failure Assessment, BMI body mass index, mo months