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Table 1 Patient demographic, hemodynamic, acid-base, and perfusion characteristics

From: Relationship of mottling score, skin microcirculatory perfusion indices and biomarkers of endothelial dysfunction in patients with septic shock: an observational study

 All patients, n = 8928-day survivors, n = 6428-day non-survivors, n = 25p value
Demographics
 Age (years)70 (62–78)69 (61–78)72 (58–77)0.31
 Male, n (%) 39 (61%)14 (56%)0.81
 APACHE II23 (18–27)21 (17–25)29 (23–33)< 0.001
 SOFA9 (7–12)8 (6–10)12 (10–13)< 0.001
 Mechanical ventilation32 (36%)17 (43%)15 (75%)0.03
Source
 Respiratory2 (26%)11 (17%)12 (48%)n/a
 Abdominal31 (35%)26 (41%)5 (20%)n/a
 Urinary26 (29%)22 (34%)4 (16%)n/a
 Others9 (%)5 (8%)4 (16%)n/a
 Temperature (°C)37.3 (36.7–38.5)37.2 (36.8–38.4)37.4 (36.6–38.9)0.91
 Hematocrit (%)35 (29–39)33 (28–39)37 (32–39)0.23
 Hemoglobin (g/dL)12.3 (10.4–13.8)12.2 (10.4–13.8)12.4 (10.9–13.9)0.87
 Bilirubin (mcmol/L)17.5 (9.0–29.0)18 (10–32)15 (6–26)0.25
Hemodynamics
 HR, beats/min100 (91–115)96 (91–103)102 (94–112)0.81
 MAP, mmHg75 (67–85)79 (68–85)71 (65–87)0.39
 CVP, mmHg8 (5–12)7 (6–11)9 (7–13)0.59
Resuscitation before HSI
 Fluids, mL3360 (2525–3394)3552 (3164–3786)3290 (2518–3576)0.71
 Noradrenaline dose, mcg/kg/min0.11 (0.08–0.17)0.1 (0.06–0.14)0.15 (0.1–0.27)0.003
 Duration of noradrenaline infusion, h14 (5–23)14 (7–23)11 (3–21)0.23
 Dobutamine, n (%)9 (10%)6 (9%)3 (12%)0.85
 Dobutamine dose, mcg/kg/min9.2 (7.6–12.1)8.9 (7.8–12.1)9.5 (7.6–13.0)0.68
Acid-base parameters
 pH (arterial)7.36 (7.28–7.47)7.39 (7.31–7.46)7.31 (7.21–7.37)0.007
 PaCO2, mmHg31 (27–36)30 (27–35)33 (29–37)0.18
 PaO2, mmHg93 (72–126)88 (69–120)107 (77–127)0.44
 PaO2/FiO2, mmHg250 (173–332)263 (195–374)191 (145–254)0.04
Perfusion parameters
 Lactate, mmol/L2.3 (1.2–4.1)2.6 (1.9–4.2)3.7 (2.0–5.4)0.3
 Mottling score0 (0;4)0 (0;3)0 (0;4)< 0.001
  062 (69%)51 (80%)11 (40%)n/a
  110 (11%)8 (13%)2 (8%)n/a
  214 (16%)4 (6%)10 (40%)n/a
  33 (3%)1 (2%)2 (8%)n/a
  41 (1%)01 (4%)n/a
  1. Values are expressed as median (interquartile range) or count (percentage). Mottling score is reported as median (range)
  2. APACHE II Acute Physiology, Age, Chronic Health Evaluation II; SOFA Sequential Organ Failure Assessment; n/a not applicable