Table 1 Patient characteristics (at ICU admission and at the start of CytoSorb or CRRT)
Characteristics | CytoSorb (N = 67) | CRRT only (n = 48) | Unadjusted p value | sIPTW-adjusted p value |
|---|---|---|---|---|
Demography | ||||
 Age, years (Mean, SD) | 61.1 (14.7) | 68.7 (9.6) | 0.001 | 0.126 |
 Male, n (%) | 37 (55%) | 30 (61%) | 0.522 | 0.021 |
Comorbidity, n (%) | ||||
 Any comorbidity | 43 (64%) | 42 (88%) | 0.002 | 0.601 |
 Diabetes mellitus type 2 | 14 (21%) | 20 (41%) | 0.024 | 0.778 |
 Hypertension | 23 (34%) | 26 (53%) | 0.046 | 0.409 |
 Coronary heart disease | 9 (13%) | 8 (16%) | 0.667 | 0.064 |
 Heart failure (systolic/diastolic) | 4 (6%) | 10 (20%) | 0.030 | 0.501 |
 Prior chronic kidney disease | 8 (12%) | 18 (37%) | 0.003 | 0.002 |
 Peripheral artery disease | 10 (15%) | 8 (16%) | 0.839 | 0.021 |
 Cerebrovascular accident | 6 (9%) | 3 (6%) | 0.577 | 0.369 |
 COPD | 8 (12%) | 10 (20%) | 0.233 | 0.002 |
Primary diagnosis, n (%) | ||||
 Abdominal sepsis | 31 (46%) | 12 (25%) | 0.014 | 0.870 |
 Pneumosepsis | 14 (21%) | 21 (43%) | 0.014 | 0.275 |
 Urosepsis | 2 (3%) | 6 (12%) | 0.078 | 0.217 |
 Cutaneous/arthritis | 9 (13%) | 3 (6%) | 0.182 | 0.064 |
 Vascular sepsis | 5 (8%) | 0 | 0.024 | 0.026 |
 Cerebral sepsis | 0 | 1 (2%) | 0.322 | 0.475 |
 Sepsis (unknown cause) | 6 (9%) | 6 (12%) | 0.569 | 0.755 |
Admission | ||||
 Surgical (otherwise medical) | 27 (40%) | 6 (12%) | < 0.001 | 0.994 |
 Days on ICU | 9 (2–19) | 9 (3–13) | 0.783 | 0.463 |
Hemodynamics (Mean, SD) | ||||
 Lactate at admission | 6.4 (5.1) | 4.4 (4.4) | 0.027 | 0.421 |
 Lactate at the start of therapy | 6.9 (5.6) | 2.9 (3.1) | < 0.001 | 0.544 |
 Noradrenaline (μg/kg/min) adm. | 0.48 (0.55) | 0.29 (0.40) | 0.052 | 0.073 |
 Noradrenaline (μg/kg/min) Rx | 0.96 (0.73) | 0.28 (0.36) | < 0.001 | 0.769 |
 Total duration noradrenaline (days) | 3 (1–5) | 3 (1–5) | 0.979 | 0.222 |
 Duration noradrenaline from Rx (days) | 2 (1–3) | 1 (0–2) | 0.694 | 0.989 |
 MAP at admission | 73 (19) | 74 (20) | 0.748 | 0.418 |
 MAP at the start of therapy | 69 (15) | 77 (18) | 0.007 | 0.019 |
Prognostic scores | ||||
 SOFA ICU admission | 11.7 (3.3) | 11.8 (3.5) | 0.907 | 0.854 |
 SOFA at the start of treatment | 13.8 (2.8) | 12.8 (3.2) | 0.067 | 0.239 |