Table 1 Differences between ACURASYS and ROSE trials

ARDS definition

-AECC

-Berlin

Median time to enrollment from ARDS diagnosis

-16 (6–29) vs. 18 (6–31) h

-8.2 (4.0–16.4) vs. 6.8 (3.3–14.5) h

Sedation targets

-Control arm—goal Ramsay score 6 (deep sedation)

-Control arm—goal Ramsay score 2–3 (light sedation)

Ventilator strategies

-TV 6–8 ml/kg

-Low PEEP (≥ 5 cm H₂O)

-TV 6 ml/kg

-High PEEP (≥ 8 cm H₂O)

Crude 90-day mortality

-31.6% vs. 40.7%, p = 0.08

-42.5% vs. 42.8%; p = 0.93

28-day mortality

-23.7% vs. 33.3%, p = 0.05

-36.7% vs. 37.0%, p = NS

Ventilator induced lung injury

-Barotrauma: 5.1% vs. 11.7%; p = 0.03

-Pneumothorax: 4.0% vs. 11.7%; p = 0.01

-Barotrauma: 4.0% vs. 6.3%; p = 0.12

-Pneumothorax: 2.8% vs. 5.0%; p = 0.10

Other adverse effects

-None

-Serious cardiovascular events: NMBA14

vs. Control 4; p = 0.02