Impact of species and antibiotic therapy of enterococcal peritonitis on 30-day mortality in critical care—an analysis of the OUTCOMEREA database

Table 3 Univariate and multivariate models evaluating the impact of Enterococci spp. and adequacy of initial antimicrobial therapy on enterococci on day 30 mortality, with adjustment on SAPS score and septic shock at diagnosis, acquisition of IAI in ICU, and adequacy of initial antimicrobial therapy on other germs. As interaction term between adequate therapy and other than E. faecalis* alone IAI was significant, we created a variable with three classes, E. faecalis IAI was the reference

Parameters	HR	CI 95%		p value
Univariate models
No E. faecalis alone	3.545	1.247	10.079	0.018
Inappropriate IAT on Enterococcus spp.	2.612	0.991	6.883	0.052
No E. faecalis alone + inadequate IAT on Enterococcus spp.*	4.427	1.277	15.344	0.019
No E. faecalis alone + adequate IAT on Enterococcus spp.*	3.106	0.985	9.796	0.053
Multivariate models
Inappropriate IAT on Enterococcus spp.	1.445	0.498	4.195	0.498
SAPS on day 0	1.003	0.964	1.043	0.893
ICU-acquired peritonitis	3.282	1.191	9.041	0.021
Adequate IAT on other germs	1.364	0.299	6.221	0.689
Septic shock at diagnosis	11.828	1.451	96.396	0.021
No E. faecalis alone	2.283	0.730	7.141	0.156
SAPS on day 0	1.003	0.964	1.043	0.890
ICU-acquired peritonitis	2.613	0.898	7.605	0.078
Adequate IAT on other germs	1.469	0.312	6.927	0.627
Septic shock at diagnosis	11.101	1.386	88.887	0.023
No E. faecalis alone + inadequate IAT on Enterococcus spp.	2.290	0.551	9.519	0.254
No E. faecalis alone + adequate IAT on Enterococcus spp.	2.281	0.690	7.535	0.176
SAPS on day 0	1.003	0.964	1.043	0.890
ICU-acquired peritonitis	2.611	0.859	7.937	0.091
Adequate IAT on other germs	1.470	0.307	7.031	0.629
Septic shock at diagnosis	11.094	1.371	89.776	0.024

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