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Table 3 Univariate and multivariate models evaluating the impact of Enterococci spp. and adequacy of initial antimicrobial therapy on enterococci on day 30 mortality, with adjustment on SAPS score and septic shock at diagnosis, acquisition of IAI in ICU, and adequacy of initial antimicrobial therapy on other germs. *As interaction term between adequate therapy and other than E. faecalis alone IAI was significant, we created a variable with three classes, E. faecalis IAI was the reference

From: Impact of species and antibiotic therapy of enterococcal peritonitis on 30-day mortality in critical care—an analysis of the OUTCOMEREA database

Parameters HR CI 95% p value
Univariate models
 No E. faecalis alone 3.545 1.247 10.079 0.018
 Inappropriate IAT on Enterococcus spp. 2.612 0.991 6.883 0.052
 No E. faecalis alone + inadequate IAT on Enterococcus spp.* 4.427 1.277 15.344 0.019
 No E. faecalis alone + adequate IAT on Enterococcus spp.* 3.106 0.985 9.796 0.053
Multivariate models
 Inappropriate IAT on Enterococcus spp. 1.445 0.498 4.195 0.498
 SAPS on day 0 1.003 0.964 1.043 0.893
 ICU-acquired peritonitis 3.282 1.191 9.041 0.021
 Adequate IAT on other germs 1.364 0.299 6.221 0.689
 Septic shock at diagnosis 11.828 1.451 96.396 0.021
 No E. faecalis alone 2.283 0.730 7.141 0.156
 SAPS on day 0 1.003 0.964 1.043 0.890
 ICU-acquired peritonitis 2.613 0.898 7.605 0.078
 Adequate IAT on other germs 1.469 0.312 6.927 0.627
 Septic shock at diagnosis 11.101 1.386 88.887 0.023
 No E. faecalis alone + inadequate IAT on Enterococcus spp. 2.290 0.551 9.519 0.254
 No E. faecalis alone + adequate IAT on Enterococcus spp. 2.281 0.690 7.535 0.176
 SAPS on day 0 1.003 0.964 1.043 0.890
 ICU-acquired peritonitis 2.611 0.859 7.937 0.091
 Adequate IAT on other germs 1.470 0.307 7.031 0.629
 Septic shock at diagnosis 11.094 1.371 89.776 0.024