Table 3 Univariate and multivariate models evaluating the impact of Enterococci spp. and adequacy of initial antimicrobial therapy on enterococci on day 30 mortality, with adjustment on SAPS score and septic shock at diagnosis, acquisition of IAI in ICU, and adequacy of initial antimicrobial therapy on other germs. *As interaction term between adequate therapy and other than E. faecalis alone IAI was significant, we created a variable with three classes, E. faecalis IAI was the reference
Parameters | HR | CI 95% | p value | |
|---|---|---|---|---|
Univariate models | ||||
No E. faecalis alone | 3.545 | 1.247 | 10.079 | 0.018 |
Inappropriate IAT on Enterococcus spp. | 2.612 | 0.991 | 6.883 | 0.052 |
No E. faecalis alone + inadequate IAT on Enterococcus spp.* | 4.427 | 1.277 | 15.344 | 0.019 |
No E. faecalis alone + adequate IAT on Enterococcus spp.* | 3.106 | 0.985 | 9.796 | 0.053 |
Multivariate models | ||||
Inappropriate IAT on Enterococcus spp. | 1.445 | 0.498 | 4.195 | 0.498 |
SAPS on day 0 | 1.003 | 0.964 | 1.043 | 0.893 |
ICU-acquired peritonitis | 3.282 | 1.191 | 9.041 | 0.021 |
Adequate IAT on other germs | 1.364 | 0.299 | 6.221 | 0.689 |
Septic shock at diagnosis | 11.828 | 1.451 | 96.396 | 0.021 |
No E. faecalis alone | 2.283 | 0.730 | 7.141 | 0.156 |
SAPS on day 0 | 1.003 | 0.964 | 1.043 | 0.890 |
ICU-acquired peritonitis | 2.613 | 0.898 | 7.605 | 0.078 |
Adequate IAT on other germs | 1.469 | 0.312 | 6.927 | 0.627 |
Septic shock at diagnosis | 11.101 | 1.386 | 88.887 | 0.023 |
No E. faecalis alone + inadequate IAT on Enterococcus spp. | 2.290 | 0.551 | 9.519 | 0.254 |
No E. faecalis alone + adequate IAT on Enterococcus spp. | 2.281 | 0.690 | 7.535 | 0.176 |
SAPS on day 0 | 1.003 | 0.964 | 1.043 | 0.890 |
ICU-acquired peritonitis | 2.611 | 0.859 | 7.937 | 0.091 |
Adequate IAT on other germs | 1.470 | 0.307 | 7.031 | 0.629 |
Septic shock at diagnosis | 11.094 | 1.371 | 89.776 | 0.024 |