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Table 2 Comparison between patients who received an appropriate initial antimicrobial therapy against Enterococcus species isolated from peritoneal sample versus patients who did not and between the groups E. faecalis alone and Enterococcus other than E. faecalis alone. Results expressed in numbers (percentages) apart from *median and interquartile interval [1st–3rd]. **Diagnosed within 48 h preceding IAI diagnosis. IAI intraabdominal infections

From: Impact of species and antibiotic therapy of enterococcal peritonitis on 30-day mortality in critical care—an analysis of the OUTCOMEREA database

Variables Initial antimicrobial therapy inactive against Enterococcus (n = 18) Initial antimicrobial therapy active against Enterococcus (n = 58) p Enterococcus other than E. faecalis alone (n = 34) E. faecalis alone without other Enterococcus species (n = 42) p
Antimicrobial therapy use < 3 months prior to IAI 9 (50.0) 34 (58.6) 0.519 26 (76.5) 17 (40.5) 0.002
Third-generation cephalosporin use < 3 months prior to IAI 6 (33.3) 7 (12.1) 0.036 9 (26.5) 4 (9.5) 0.051
Hospital admission-IAI time* 4 [2–7] 10 [3–22] 0.016 10 [3–24] 6 [2–13] 0.104
ICU admission-IAI time* 1 [1–4] 1 [1–5] 0.622 2 [1–7] 1 [1–1] 0.024
IAI diagnosis-surgery time* 0 [0–0] 0 [0–0] 0.728 0 [0–0] 0 [0–0] 0.986
Postoperative IAI 7 (38.9) 18 (79.3) 0.001 23 (67.6) 30 (71.4) 0.721
ICU-acquired IAI 8 (44.4) 16 (27.6) 0.179 15 (44.1) 9 (21.4) 0.034
SAPS on day 0* 56.5 [39–63] 45.5 [37–55] 0.029 50.0 [39–60] 45.5 [36–54] 0.051
Day 0 vasopressor use 14 (77.8) 40 (69.0) 0.471 27 (79.4) 27 (64.3) 0.148
Septic shock at diagnosis 15 (83.3) 38 (65.5) 0.151 26 (76.5) 27 (64.3) 0.250
Pneumonia** 1 (5.6) 1 (1.7) 0.375 1 (2.9) 1 (2.4) 0.879
Other bacteremia** 2 (11.1) 4 (6.9) 0.562 2 (5.9) 4 (9.5) 0.558
Catheter-related bloodstream infection** 0 (0) 3 (5.2) 0.151 1 (2.9) 2 (4.8) 0.685
Adequate initial antimicrobial therapy against other germs 14 (77.8) 50 (86.2) 0.392 28 (82.4) 36 (85.7) 0.689
Inadequate initial antimicrobial therapy against identified Enterococcus 18 (100) 0 (0) < 0.001 22 (64.7) 36 (85.7) 0.032
Vancomycin in initial antimicrobial regimen 1 (5.6) 22 (37.9) 0.009    
E. faecium isolated in peritoneal sample 11 (61.1) 17 (29.3) 0.015    
E. faecalis isolated in peritoneal sample 8 (44.4) 38 (65.5) 0.110    
Other Enterococcus isolated in peritoneal sample 2 (11.1) 7 (12.1) 0.913    
Day 30 surgical complications 8 (44.4) 27 (46.6) 0.875 15 (44.1) 20 (47.6) 0.761
Day 30 relaparotomy or percutaneous drainage 4 (22.2) 19 (32.8) 0.395 7 (20.6) 16 (38.1) 0.099
Day 30 infectious complications 7 (38.9) 17 (29.3) 0.445 12 (35.3) 12 (28.6) 0.531
Day 30 mortality 7 (38.9) 10 (17.2) 0.054 12 (35.3) 5 (11.9) 0.015
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Critical Care

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