Table 2 Comparison between patients who received an appropriate initial antimicrobial therapy against Enterococcus species isolated from peritoneal sample versus patients who did not and between the groups E. faecalis alone and Enterococcus other than E. faecalis alone. Results expressed in numbers (percentages) apart from *median and interquartile interval [1st–3rd]. **Diagnosed within 48 h preceding IAI diagnosis. IAI intraabdominal infections
Variables | Initial antimicrobial therapy inactive against Enterococcus (n = 18) | Initial antimicrobial therapy active against Enterococcus (n = 58) | p | Enterococcus other than E. faecalis alone (n = 34) | E. faecalis alone without other Enterococcus species (n = 42) | p |
|---|---|---|---|---|---|---|
Antimicrobial therapy use < 3 months prior to IAI | 9 (50.0) | 34 (58.6) | 0.519 | 26 (76.5) | 17 (40.5) | 0.002 |
Third-generation cephalosporin use < 3 months prior to IAI | 6 (33.3) | 7 (12.1) | 0.036 | 9 (26.5) | 4 (9.5) | 0.051 |
Hospital admission-IAI time* | 4 [2–7] | 10 [3–22] | 0.016 | 10 [3–24] | 6 [2–13] | 0.104 |
ICU admission-IAI time* | 1 [1–4] | 1 [1–5] | 0.622 | 2 [1–7] | 1 [1–1] | 0.024 |
IAI diagnosis-surgery time* | 0 [0–0] | 0 [0–0] | 0.728 | 0 [0–0] | 0 [0–0] | 0.986 |
Postoperative IAI | 7 (38.9) | 18 (79.3) | 0.001 | 23 (67.6) | 30 (71.4) | 0.721 |
ICU-acquired IAI | 8 (44.4) | 16 (27.6) | 0.179 | 15 (44.1) | 9 (21.4) | 0.034 |
SAPS on day 0* | 56.5 [39–63] | 45.5 [37–55] | 0.029 | 50.0 [39–60] | 45.5 [36–54] | 0.051 |
Day 0 vasopressor use | 14 (77.8) | 40 (69.0) | 0.471 | 27 (79.4) | 27 (64.3) | 0.148 |
Septic shock at diagnosis | 15 (83.3) | 38 (65.5) | 0.151 | 26 (76.5) | 27 (64.3) | 0.250 |
Pneumonia** | 1 (5.6) | 1 (1.7) | 0.375 | 1 (2.9) | 1 (2.4) | 0.879 |
Other bacteremia** | 2 (11.1) | 4 (6.9) | 0.562 | 2 (5.9) | 4 (9.5) | 0.558 |
Catheter-related bloodstream infection** | 0 (0) | 3 (5.2) | 0.151 | 1 (2.9) | 2 (4.8) | 0.685 |
Adequate initial antimicrobial therapy against other germs | 14 (77.8) | 50 (86.2) | 0.392 | 28 (82.4) | 36 (85.7) | 0.689 |
Inadequate initial antimicrobial therapy against identified Enterococcus | 18 (100) | 0 (0) | < 0.001 | 22 (64.7) | 36 (85.7) | 0.032 |
Vancomycin in initial antimicrobial regimen | 1 (5.6) | 22 (37.9) | 0.009 | |||
E. faecium isolated in peritoneal sample | 11 (61.1) | 17 (29.3) | 0.015 | |||
E. faecalis isolated in peritoneal sample | 8 (44.4) | 38 (65.5) | 0.110 | |||
Other Enterococcus isolated in peritoneal sample | 2 (11.1) | 7 (12.1) | 0.913 | |||
Day 30 surgical complications | 8 (44.4) | 27 (46.6) | 0.875 | 15 (44.1) | 20 (47.6) | 0.761 |
Day 30 relaparotomy or percutaneous drainage | 4 (22.2) | 19 (32.8) | 0.395 | 7 (20.6) | 16 (38.1) | 0.099 |
Day 30 infectious complications | 7 (38.9) | 17 (29.3) | 0.445 | 12 (35.3) | 12 (28.6) | 0.531 |
Day 30 mortality | 7 (38.9) | 10 (17.2) | 0.054 | 12 (35.3) | 5 (11.9) | 0.015 |