Skip to main content
Fig. 5 | Critical Care

Fig. 5

From: Interleukin-26 is overexpressed in human sepsis and contributes to inflammation, organ injury, and mortality in murine sepsis

Fig. 5

Effect of recombinant human IL-26 on cecal ligation and puncture (CLP)-induced inflammation and injury of vital organs and death. a Survival of CLP mice (n = 20 per group) after treatment with recombinant human IL-26 in the absence or presence of CLP-induced sepsis. Recombinant human IL-26 was injected intraperitoneally at 0.5–1.0 μg/injection immediately after CLP, and PBS was delivered in a similar fashion as control solutions. Comparison between groups was done by Kaplan–Meier analysis followed by log-rank tests. Results are representative of three independent experiments. b Serological markers of organ injury including alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and creatinine in mice (n = 5 per group) treated with or without recombinant IL-26 (0.5 μg) at 24 h after CLP. Statistical difference was denoted by the horizontal bracket (Mann–Whitney U test). c Representative examples of hematoxylin and eosin (H&E)-stained lung, liver, spleen, and kidney tissues from mice (n = 5 per group) treated with or without recombinant human IL-26 (0.5 μg) at 24 h after CLP. d Histological scores for lung, liver, spleen, and kidney tissues from mice (n = 5 per group) treated with or without recombinant human IL-26 (0.5 μg) at 24 h after CLP. Statistical difference was denoted by the horizontal bracket (Mann–Whitney U test)

Back to article page